Assessment of Preload Dependency Via Measurement of Peripheral Venous Pressure During an Alveolar Recruitment Manoeuvre
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Intensive Care Patients
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
- Enrollment
- 21
- Locations
- 1
- Primary Endpoint
- Primary outcome measure
- Status
- Terminated
- Last Updated
- last year
Overview
Brief Summary
Assessment of preload dependency via measurement of peripheral venous pressure during an alveolar recruitment manoeuvre.
Prospective multicentre open-label study of mechanically ventilated intensive care patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients aged 18 years or older, for whom the trusted person designated by the patient or, failing that, a relative has read and signed the consent form for participation in the study
- •Patient hospitalised in intensive care, under sedation and controlled mechanical ventilation
- •Equipped with a central venous line in the superior vena cava territory and an arterial catheter.
- •Whose state of health justifies vascular filling
Exclusion Criteria
- •Patient under legal protection, guardianship or curatorship
- •Pregnant or breastfeeding woman
- •Patient not affiliated to the French social security system
- •Contraindication to the realization of an alveolar recruitment maneuver
Outcomes
Primary Outcomes
Primary outcome measure
Time Frame: through study completion, an average of 12 hours
The correlation between the pairs of values of CVP and PVP during an alveolar recruitment manoeuvre will be evaluated by Pearson's coefficient or Spearman's coefficient if the distribution of the values is not parametric. The coefficient of determination r² will be calculated by linear regression between the 2 variables. Finally, the agreement between the two measurements will be evaluated by the Bland-Altman method: the Bland-Altman graph will be provided and the 95% agreement limits will be calculated (+/- 1.96 SD, SD being the standard deviation of the difference between the measurements).
Secondary Outcomes
- Secondary outcome measure(through study completion, an average of 12 hours)