Noninvasive Assessment of Preload Dependency by Passive Leg Raising Test and Impedance Cardiography Compared to Echocardiographic Measurements After Cardiac Surgery

University Hospital, Strasbourg, France1 site in 1 country65 target enrollmentMay 2014

ConditionsCardiac Surgery With Extracorporeal Circulation

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Cardiac Surgery With Extracorporeal Circulation
Sponsor: University Hospital, Strasbourg, France
Enrollment: 65
Locations: 1
Primary Endpoint: Area under ROC curve comparing SV variation (impedance cardiography) and VTI variation after PLR
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The primary purpose of this study is to investigate wether the measure of stroke volume (SV) variations by impedance cardiography during passive leg raising (PLR) can reliably predict preload dependency after cardiac surgery, in comparison to a reference parameter : velocity time integral (VTI) variation measured by transthoracical echocardiography.

Registry

clinicaltrials.gov

Start Date

May 2014

End Date

May 2016

Last Updated

9 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University Hospital, Strasbourg, France

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Men or women over 18 years
•Affiliated to a social protection
•Signed written consent
•Informed about the results of the medical visit
•All type of cardiac surgery with extracorporeal circulation performed at University Hospital of Strasbourg
•Sedated and under mechanical ventilation

Exclusion Criteria

•Cardiac arrhythmia
•Contraindication to PLR maneuver
•Exclusion period due to inclusion in a previous or ongoing study
•Impossibility to provide enlightened information
•Patient deprived of liberty, under judicial protection, trusteeship or guardianship
•Pregnancy, lactation

Outcomes

Primary Outcomes

Area under ROC curve comparing SV variation (impedance cardiography) and VTI variation after PLR

Time Frame: Within the 6 first hours after cardiac surgery

Patients classified as responders and non responders to PLR : VTI variation ≥ 12% or \< 12%

Secondary Outcomes

Variation of central veinous pressure, left auricular pressure and left ventricular filling pressures after PLR (ROC curves, correlation tests)(Within the 6 first hours after cardiac surgery)
Respiratory variation of inferior vena cava(Within the 6 first hours after cardiac surgery)