Stroke Volume Variation and Pulse Pressure Variation as Predictors of Fluid Responsiveness During Kidney Transplantation

Not Applicable

Completed

• Conditions: Kidney Transplantation
• Interventions: Procedure: Fluid loading

• Registration Number: NCT02459470
• Lead Sponsor: Samsung Medical Center

Brief Summary

The aim pf this prospective study is to investigate the ability of stroke volume variation (SVV) and pulse pressure variation (PPV) to predict fluid responsiveness in patients undergoing kidney transplantation.

Detailed Description

Optimal intraoperative fluid management guided by central venous pressure (CVP), a traditional intravascular volume status indicator has been established to improve transplanted graft function during renal transplantation. Recently, stroke volume variation (SVV) and pulse pressure variation (PPV), dynamic preload indices derived from the arterial waveform are increasingly advocated as predictors of fluid responsiveness in anesthetized patients and critically ill patients. However, their usefulness in renal failure patients undergoing renal transplantation has not been investigated. Thus, the aims of this study is to investigate accuracy of SVV and PPV for predicting fluid responsiveness in patients undergoing kidney transplantation.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Status Verified: 2012-12
• Study Start: 2012-12
• Primary Completion: 2013-12
• Study Completion: 2013-12
• Study First Submitted: 2015-05-14
• Study First Submitted QC: 2015-05-28
• Last Update Submitted: 2015-05-28
• Study First Posted: 2015-06-02
• Last Update Posted: 2015-06-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

• chronic renal failure patients undergoing renal transplantation

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Exclusion Criteria

• patients with cardiac arrhythmia
• patients with reduced left ventricular function (EF < 40%)
• patients with valvular heart disease
• patients intracardiac shunt
• patients with pulmonary hypertension
• patients with extensive peripheral vascular disease
• patients with preoperative use of vasopressors or inotropics

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
SVV and PPV	Fluid loading	SVV(stroke volume variation): recorded using the Flotrac/Vigileo system (Edwards Lifesciences) PPV(pulse pressure variation): recorded using philips Intelivue MP70 monitors (Philips Medical System) Intervention: Other: Fluid loading using HES 130/0.4; voluven; Fresenius Kabi; Stans, Switzerland

Primary Outcome Measures

Name	Time	Method
stroke volume variation from Flo stroke volume variation from FloTrac/Vigileo system	within 5 minutes after fluid expansion	predictable of stroke volume variation from FloTrac/Vigileo system for fluid responsiveness
pulse pressure variation from philips Intelivue MP70 monitor	within 5 minutes after fluid expansion	predictable of pulse pressure variation from philips Intelivue MP70 monitor for fluid responsiveness

Trial Locations

Locations (1)

Samsung Seoul Hospital, Samsung Medical Center; 🇰🇷 Seoul, Korea, Republic of