Utility of Stroke Volume Variation and Pulse Pressure Variation for Predicting Fluid Responsiveness in Chronic Renal Failure Patients Undergoing Kidney Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 42
- 试验地点
- 2
- 主要终点
- stroke volume variation from Flo stroke volume variation from FloTrac/Vigileo system
研究概览
简要总结
The aim pf this prospective study is to investigate the ability of stroke volume variation (SVV) and pulse pressure variation (PPV) to predict fluid responsiveness in patients undergoing kidney transplantation.
详细描述
Optimal intraoperative fluid management guided by central venous pressure (CVP), a traditional intravascular volume status indicator has been established to improve transplanted graft function during renal transplantation. Recently, stroke volume variation (SVV) and pulse pressure variation (PPV), dynamic preload indices derived from the arterial waveform are increasingly advocated as predictors of fluid responsiveness in anesthetized patients and critically ill patients. However, their usefulness in renal failure patients undergoing renal transplantation has not been investigated. Thus, the aims of this study is to investigate accuracy of SVV and PPV for predicting fluid responsiveness in patients undergoing kidney transplantation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •chronic renal failure patients undergoing renal transplantation
排除标准
- •patients with cardiac arrhythmia
- •patients with reduced left ventricular function (EF < 40%)
- •patients with valvular heart disease
- •patients intracardiac shunt
- •patients with pulmonary hypertension
- •patients with extensive peripheral vascular disease
- •patients with preoperative use of vasopressors or inotropics
研究组 & 干预措施
SVV and PPV
SVV(stroke volume variation): recorded using the Flotrac/Vigileo system (Edwards Lifesciences)
PPV(pulse pressure variation): recorded using philips Intelivue MP70 monitors (Philips Medical System)
Intervention: Other: Fluid loading using HES 130/0.4; voluven; Fresenius Kabi; Stans, Switzerland
干预措施: Fluid loading (Procedure)
结局指标
主要结局
stroke volume variation from Flo stroke volume variation from FloTrac/Vigileo system
时间窗: within 5 minutes after fluid expansion
predictable of stroke volume variation from FloTrac/Vigileo system for fluid responsiveness
pulse pressure variation from philips Intelivue MP70 monitor
时间窗: within 5 minutes after fluid expansion
predictable of pulse pressure variation from philips Intelivue MP70 monitor for fluid responsiveness
次要结局
未报告次要终点