Restrictive Versus Liberal Stroke Volume Variation-guided Fluid Infusion in Major Liver Tumour Resection: a Prospective Randomised Trial of Perioperative Quality of Care
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 118
- 试验地点
- 2
- 主要终点
- The incidence of postoperative complications in the two groups.
研究概览
简要总结
Studies have demonstrated that the rate of change in stroke volume variation (SVV) can be used to determine the volume of body fluids during major abdominal surgery. Anaesthesiologists can use SVV as a guide for the appropriate administration of intraoperative fluids to improve postoperative prognoses. Liver surgery is a major abdominal operation, and the amount of blood lost is typically higher than that during other general abdominal surgeries. Blood loss is positively correlated with the intraoperative fluid infusion volume, and greater blood loss is associated with more postoperative complications. Additionally, comorbid liver disease or cirrhosis can increase the complexity of liver tumour resection, causing difficulty in assessing intravascular volume and determining the appropriate intraoperative infusion volume.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •We initially selected 118 patients who required hepatectomy.
- •The physiological status of the patients was assessed in terms of American Society of Anesthesiologists scores I-III
排除标准
- •Extreme body mass index (BMI)
- •Age under 20 or over 75 years
- •Emergency surgery
- •Preexisting cardiac, hepatic, renal, or coagulation disorder; hyperthyroidism; and sinus arrhythmia.
结局指标
主要结局
The incidence of postoperative complications in the two groups.
时间窗: From day 1 to day 30 after surgery.
calculate the incidence of postoperative complication within 30 days
次要结局
- The differences of perioperative ALT(Examination report on the 1st postoperative day.)
- The differences of perioperative T.bil(Examination report on the 1st postoperative day.)
- The differences of perioperative arterial lactate(Examination report on the 1st postoperative day.)
- The differences of perioperative albumin(Examination report on the 1st postoperative day.)
- The differences of perioperative creatinine(Examination report on the 1st postoperative day.)
- The differences of perioperative Hb(Examination report on the 1st postoperative day.)
- The pain scale(up to three days postoperatively)
- The differences of perioperative eGFR(Examination report on the 1st postoperative day.)
研究者
Yuan-Yi Chia
Chief of Anesthesiology
Kaohsiung Veterans General Hospital.