A RANDOMIZED DOUBLE BLINDED COMPARITIVE STUDY OF INSTILLATION OF BUPRENORPHINE VS PLACEBO IN EPIDURAL SPACE FOR POSTOPERATIVE ANALGESIA IN POST LAMINECTOMY PATIENTS
概览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- Department of Anaesthesiology
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Pain by Numerical pain rating scale
概览
简要总结
Immediate postoperative pain relief after surgery can significantly affect the outcome of surgical procedures and operative morbidity. Parenteral opioids are the mainstay of treatment for postoperative pain after laminectomy. But these are usually given with large time lapses which cause fluctuations in clinical effect. The epidural injection of opioids has proven to be effective and has a longer duration of action in relieving postoperative pain. Postoperative pain management for spinal surgery with epidural infusion of morphine and fentanyl has been widely reported. Buprenorphine, because it is more potent and more lipid-soluble and has a longer duration of action, is said to have advantages over morphine for epidural use in postoperative pain relief.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients willing to give informed and written consent ASA physical status I & II Patients with body weight 50-80kgs.
排除标准
- •ASA physical status III and above.
- •Patients who have known hypersensitivity to the study drugs Patients with history of neuromuscular disease Patients with history of substance abuse.
结局指标
主要结局
Pain by Numerical pain rating scale
时间窗: 1st, 2nd, 3rd, 4th, 5th, 6th, 12th, 18th and 24 hours
次要结局
- Pulse Rate(Mean Arterial Pressure)
研究者
Dr Yoganarasimha N
BGS Global Institute of Medical Sciences