A RANDOMIZED DOUBLE BLINDED COMPARITIVE STUDY OF INSTILLATION OF BUPRENORPHINE VS PLACEBO IN EPIDURAL SPACE FOR POSTOPERATIVE ANALGESIA IN POST LAMINECTOMY PATIENTS
Overview
- Phase
- Phase 3 4
- Status
- Not yet recruiting
- Sponsor
- Department of Anaesthesiology
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Pain by Numerical pain rating scale
Overview
Brief Summary
Immediate postoperative pain relief after surgery can significantly affect the outcome of surgical procedures and operative morbidity. Parenteral opioids are the mainstay of treatment for postoperative pain after laminectomy. But these are usually given with large time lapses which cause fluctuations in clinical effect. The epidural injection of opioids has proven to be effective and has a longer duration of action in relieving postoperative pain. Postoperative pain management for spinal surgery with epidural infusion of morphine and fentanyl has been widely reported. Buprenorphine, because it is more potent and more lipid-soluble and has a longer duration of action, is said to have advantages over morphine for epidural use in postoperative pain relief.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
Eligibility Criteria
- Ages
- 20.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients willing to give informed and written consent ASA physical status I & II Patients with body weight 50-80kgs.
Exclusion Criteria
- •ASA physical status III and above.
- •Patients who have known hypersensitivity to the study drugs Patients with history of neuromuscular disease Patients with history of substance abuse.
Outcomes
Primary Outcomes
Pain by Numerical pain rating scale
Time Frame: 1st, 2nd, 3rd, 4th, 5th, 6th, 12th, 18th and 24 hours
Secondary Outcomes
- Pulse Rate(Mean Arterial Pressure)
Investigators
Dr Yoganarasimha N
BGS Global Institute of Medical Sciences