Effect of Airway Pressure Release Ventilation on patient' hemodynamic after Coronary Artery Bypass Graft
Trial Snapshot
- Phase
- 未知
- Status
- Completed
- Sponsor
- Enrollment
- 32
Study Overview
Brief Summary
Background and purpose: Following coronary artery bypass grafting (CABG) respiratory failure is inevitable, therefore, invasive ventilation is used in patients. This study was conducted to investigate the effect of airway pressure release ventilation (APRV) on arterial blood gas (ABG) of patients after CABG.
Materials and methods: This study was conducted in 32 patients in Mashhad Imam Reza Hospital, 2014. The patients were randomly divided into two groups (n= 16 per group). The two groups received synchronized intermittent mandatory ventilation (SIMV). Then the patients in group I were switched to APRV while in group II SIMV continued for another half an hour. Afterwards, group I received SIMV and group II received APRV for half an hour. In all three stages the values for ABG were recorded. Data was then analyzed in SPSS.
Results: The mean values of PaCO2 showed no significant changes in three stages between the two groups (P>0.05) but the mean values of PaO2 in APRV stage in first group (P< 0.001 and P< 0.01) and second group (P< 0.003 and P< 0.002) showed significant increases compared to that of the first and second SIMV mode.
Conclusion: APRV led to improvement of oxygenation.
Keywords: continuous positive airway pressure, blood gas analysis, Coronary Artery Bypass Grafting
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 40 years to 70 years (—)
- Sex
- All
Inclusion Criteria
- •age between 40-70 years old; hemodynamic stability in the first visit; EF = 40% ; RASS = -2 to -3; surgery OFF PUMP; CABG without repair or replace the valve; failure to perform CPR during surgery or before the study; failure to perform emergency surgery (out of routine preoperative); absence of underlying lung disease; lack of oxygenation and ventilation disorder; having hypertension before surgery.
- •Exclusion criteria: CPR performed during study; the need to replace volume; -2< RASS <-3; bleeding more than 100ml / hr of Drains; need to have surgery again; pH arterial <7.25; dysrhythmia that lead to the development of hemodynamic changes.
Exclusion Criteria
- Not provided