The Spread of Aerosols During Respiratory Manoeuvres and During Administration of Respiratory Support in Patients with Respiratory Disease and Healthy Volunteers

Not Applicable

• Conditions: Public Health - Health service research; Airborne viral transmission via respiratory aerosols; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12621001237875
• Lead Sponsor: Woolcock Institute of Medical Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-09-13
• Last Update Posted: 20 September 2021

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

Healthy Participants
Subjects recruited will have normal lung function with no underlying physician-diagnosed respiratory disease and satisfy the following criteria:
• Non-smoker with pack years < 10 years
• BMI < 30kg/m3

Respiratory Disease Patients
Subjects recruited will be admitted to RNSH with resolved infective pulmonary pathology, or attending outpatient clinics with physician-diagnosed respiratory disease

Exclusion Criteria

Healthy Participants
• No Intensive Care Unit admissions in the last 12 months.
• Active or chronic respiratory pathologies (for example, interstitial lung disease, asthma, chest wall pathology causing ventilatory restriction)
• History of lung surgery (including lobectomy or pneumonectomy, but not lung biopsy) or thoracic radiation therapy (excluding isolated mediastinal radiation therapy with no evidence of subsequent pulmonary fibrosis)
• Any major comorbidities deemed to impact on respiratory physiology or symptoms, including severe on uncontrolled heart failure, morbid obesity (BMI >40), muscular or neurological disorders causing respiratory muscle weakness or dysfunctional swallowing
• History of chronic kidney disease (creatine greater than the upper limit of normal)
• Unable to perform lung function testing
• Women who are breast feeding, pregnant, or unwilling to avoid pregnancy during the study period
• Unable to provide informed consent

Respiratory Disease Patients
• Unable to perform lung function testing
• Serious comorbidities that put the patient at risk when performing spirometry or during the administration of breathing support
• Unable to provide informed consent
• Known infective Tuberculosis, viral respiratory infection, or HIV.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The total number of particles in room air during common respiratory manoeuvres and administration of breathing support in both healthy and diseased participants will be measured using an optical particle sizer (OPS) and high-resolution electrical low-pressure impactor (HR-ELPI)[During the administration of respiratory support measured over a period of 15 minutes of respiratory support or common respiratory manoeuvres]

Secondary Outcome Measures

Name	Time	Method
Size distribution of particles in room air during common respiratory manoeuvres and administration of breathing support in both healthy and diseased participants will be measured using an optical particle sizer (OPS) and high-resolution electrical low-pressure impactor (HR-ELPI)[During the administration of respiratory support measured over a period of 15 minutes of respiratory support or common respiratory manoeuvres.]