Dry Eye Disease With Isotretinoin ISOTRETINOIN
Not yet recruiting
- Conditions
- Acne Vulgaris
- Registration Number
- NCT06725290
- Lead Sponsor
- Cairo University
- Brief Summary
The study aims to explore the effects of isotretinoin therapy on the dry eye parameters in acne vulgaris patients \& determine if it is dose-dependent or not.
- Detailed Description
To measure the tear film, the eye lid thickness, the meibomian gland function and to do objective tests for comparison
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- Moderate to severe acne on isotretinoin
Exclusion Criteria
- Occular diseases causing dry eye
- Pregnant females
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Total ocular surface disease index (OSDI) SCORE 3 months Total OSDI score ranged from 0 to 100 with means greater symptom severity
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
How does isotretinoin modulate retinoic acid receptor pathways in dry eye disease among acne vulgaris patients?
What comparative effectiveness data exist for isotretinoin versus topical retinoids in managing acne-related dry eye symptoms?
Which ocular biomarkers (e.g., tear film osmolarity, MMP-9) predict isotretinoin-induced dry eye severity in acne patients?
What are the evidence-based management strategies for isotretinoin-associated keratitis sicca in dermatological practice?
How do combination therapies of isotretinoin with cyclosporine A impact meibomian gland dysfunction in acne vulgaris patients?