Acute Cardiovascular Responses and Chronic Adaptations of Strength Exercise in Intermittent Claudication Patients

Not Applicable

Completed

• Conditions: Intermittent Claudication; Peripheral Artery Disease
• Interventions: Behavioral: Control; Behavioral: Resistance training

• Registration Number: NCT02778568
• Lead Sponsor: University of Pernambuco

Brief Summary

The aim of this study was to analyze the effects of resistance exercise and training on cardiovascular function of peripheral artery disease patients.

Detailed Description

Several studies have shown that strength training can promote important benefits for the cardiovascular system in healthy subjects and patients with chronic diseases. However, the effects of resistance exercise on cardiovascular function in intermittent claudication patients are unclear. In addition, it also do not know the chronic effects on cardiovascular function in these patients.

Study Timeline

• Study Start: 2010-01
• Primary Completion: 2013-12
• Study First Submitted: 2013-12-12
• Study Completion: 2015-12
• Status Verified: 2016-05
• Study First Submitted QC: 2016-05-17
• Study First Posted: 2016-05-20
• Last Update Submitted: 2016-05-23
• Last Update Posted: 2016-05-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Had a graded treadmill test that was limited by claudication (2 minutes)
• Had an ankle brachial index <0.90
• Had systolic blood pressure ,160 mmHg and/or diastolic blood pressure,105 mmHg
• Were not performing any regular exercise program
• Were not using antihypertensive medications affecting the heart rate (e.g., b-blockers and nondihydropyridine calcium channel blockers)
• Were nonobese
• Individuals who have not undergone bypass surgery or angioplasty least one year ago

Exclusion Criteria

• Had no symptoms related to myocardial ischemia during the treadmill test
• Amputation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control	Control	Patients who performed flexibility exercise
Resistance Training	Resistance training	Patients performed resistance exercises

Primary Outcome Measures

Name	Time	Method
Change in blood pressure	Change from baseline to 12 and 24 weeks

Secondary Outcome Measures

Name	Time	Method
Change in Health related Quality of life	Change from baseline to 12 and 24 weeksBaseline, 12 wks and 24 wks
Change Serum Cholesterol	Change from baseline to 12 and 24 weeks
Change in body fat	Change from baseline to 12 and 24 weeks
Change in serum glucose	Change from baseline to 12 and 24 weeks
Change in Walking distance	Change from baseline to 12 and 24 weeks
Change in Muscle blood flow of limbs	Change from baseline to 12 and 24 weeks	Muscle blood flow assessed with venous occlusion plethysmography
Change in TNFalpha	Change from baseline to 12 and 24 weeks
Change in Score Short-physical performance battery	Change from baseline to 12 and 24 weeks

Trial Locations

Locations (1)

Emergency Hospital of Pernambuco - PROCAPE; 🇧🇷 Recife, PE, Brazil