Extubation Of preterm infants: The Diagnostic utility of UltraSound (EXODUS)

Not Applicable

Completed

• Conditions: Prematurity; Respiratory distress syndrome; Respiratory - Other respiratory disorders / diseases; Reproductive Health and Childbirth - Complications of newborn

• Registration Number: ACTRN12621001356853
• Lead Sponsor: The Royal Women's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-10-07
• Study Completion: 2024-02-17
• Last Update Posted: 8 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

All infants born < 32 weeks and/or < 1250g who are mechanically ventilated for > 4 hours will be considered eligible

Exclusion Criteria

•Congenital lung malformations including congenital diaphragmatic hernia
•Genetic conditions that affect respiratory drive or effort
•Congenital upper airway anomalies.
•Previous participation in EXODUS

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The ability of the LUS aeration score derived from combined anterior and lateral imaging to predict extubation failure (EF) as defined as replacement of an endotracheal tube which will be determined by review of the medical records and communication with the treating team.[ 1. 72 hours (primary timepoint) <br>2. 24 hours post extubation <br>3. 48 hours post extubation <br>4. 7 days post extubation (outcome only, no ultrasound) ]