Bronchial Colonization With Fungi and Late Respiratory Acquired Pneumonia

Not Applicable

Completed

• Conditions: Ventilator Acquired Pneumonia
• Interventions: Procedure: biological sampling; Procedure: sampling blood; Procedure: endotracheal aspiration

• Registration Number: NCT01770015
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

Ventilator acquired pneumonia (VAP) are severe nosocomial infections. On the other side, bronchial fungi colonization is commonly observed in ICU; therefore, the investigators propose to study the role of bronchial fungi colonization on the occurrence of VAP taking into account the immune status of the patient and the antibiotic and antifungal treatments he has received.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-11
• Study First Submitted: 2012-06-21
• Study First Submitted QC: 2013-01-16
• Study First Posted: 2013-01-17
• Primary Completion: 2016-03
• Study Completion: 2016-09
• Status Verified: 2022-11
• Last Update Submitted: 2022-11-03
• Last Update Posted: 2022-11-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 213

Inclusion Criteria

• patient ventilated for at least 5 days

Exclusion Criteria

• invasive infection Candida sp defined by : candidemia, isolation of Candida from a normally sterile site, candida pneumoniae.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
ventilated patient	biological sampling	all patients underwent the same diagnostic test . cutaneous, rectal, nose and mouth swabs to identify potential fungi colonization. HLA DR antigen, cytokines (IL 6 and 10), B-glucan. fungi and bacteria endotracheal aspiration
ventilated patient	sampling blood	all patients underwent the same diagnostic test . cutaneous, rectal, nose and mouth swabs to identify potential fungi colonization. HLA DR antigen, cytokines (IL 6 and 10), B-glucan. fungi and bacteria endotracheal aspiration
ventilated patient	endotracheal aspiration	all patients underwent the same diagnostic test . cutaneous, rectal, nose and mouth swabs to identify potential fungi colonization. HLA DR antigen, cytokines (IL 6 and 10), B-glucan. fungi and bacteria endotracheal aspiration

Primary Outcome Measures

Name	Time	Method
Onset of a late ventilator acquired pneumonia (VAP)	Participants will be followed for the duration of mechanical ventilation, an expected time frame that can go from 5 days to up to 8 weeks

Secondary Outcome Measures

Name	Time	Method
Onset of a pseudomonas aeruginosa associated VAP	Participants will be followed for the duration of mechanical ventilation, an expected time frame that can go from 5 days to up to 8 weeks
Onset of late ventilator associated pneumonia associated to staphylococcus aureus	Participants will be followed for the duration of mechanical ventilation, an expected time frame that can go from 5 days to up to 8 weeks

Trial Locations

Locations (2)

Hospital University Clermont Ferrand Gabriel Montpied; 🇫🇷 Clermont-Ferrand, France

University Hospital of Grenoble; 🇫🇷 Grenoble, France