Mechanism and Efficacy of Rehabilitation Approaches

Not Applicable

Completed

• Conditions: Cerebrovascular Accidents
• Interventions: Other: Constraint-induced therapy (CIT); Other: Bilateral arm training (BAT); Other: Combined therapy (CT); Behavioral: Control intervention

• Registration Number: NCT00564005
• Lead Sponsor: Chang Gung Memorial Hospital

Brief Summary

Identify the possible mechanisms and the relative effectiveness of existing rehabilitation approaches that target upper extremity deficits of stroke patients on the ground that these approaches are based on neuroplasticity principles and sound motor control theories.

Detailed Description

Comparisons of constraint-induced therapy (CIT) vs. bilateral arm training (BIT)vs. combined therapy were made. Stroke patients will receive one of these three approaches and be evaluated pre- and post-treatment. the treatment will last 3 weeks and 5 days per week. The evaluation will include clinical measures of motor function, ADL, and quality of life, kinematic performance, and activation patterns of cortex.

Study Timeline

• Study First Submitted: 2007-11-25
• Study First Submitted QC: 2007-11-26
• Study First Posted: 2007-11-27
• Study Start: 2008-01
• Primary Completion: 2010-12
• Study Completion: 2010-12
• Status Verified: 2014-09
• Last Update Submitted: 2015-02-10
• Last Update Posted: 2015-02-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• a first-ever clinical cerebrovascular accident patients
• at least 6 months post-stroke onset
• premorbid right-hand dominance
• demonstration of Brunnstrom stage III of the affected upper extremity
• no excessive spasticity in the joints of the affected upper extremity

Exclusion Criteria

• a score of less than 24 on the Mini Mental State Exam
• poor physical conditions that would interfere with participation
• excessive pain in any joint that might limit participation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	Constraint-induced therapy (CIT)	constraint-induced therapy
2	Bilateral arm training (BAT)	bilateral arm training
3	Combined therapy (CT)	combined therapy
Control intervention	Control intervention	-

Primary Outcome Measures

Name	Time	Method
Cortical reorganization and kinematic analysis	2008-2010

Secondary Outcome Measures

Name	Time	Method
clinical measures at the impairment, activity, participation levels	2008-2010

Trial Locations

Locations (1)

Chang Gung Memorial Hospital; 🇨🇳 Kwei-shan, Toayuan county, Taiwan