Cardiovascular Rehabilitation in Coronary Artery Disease Patients: Influence of Different Types of Exercise Training on Selected Cardiovascular Parameters
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Coronary Artery Disease
- Sponsor
- University Medical Centre Ljubljana
- Enrollment
- 115
- Locations
- 1
- Primary Endpoint
- Change of flow-mediated dilatation of the brachial artery, measured in %
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
In this controlled trial, patients referred to post-myocardial infarction cardiac rehabilitation will be randomized to either interval or continuous training.
Detailed Description
The trial would i) compare the acute effects of each exercise type on selected cardiovascular indicators; ii) compare the chronic effects of each exercise type on selected cardiovascular indicators; iii) provide information on the association between acute and chronic effects of each exercise type; iv) provide insight into possible mechanisms of effectiveness of each exercise type; v) identify the most safe and effective exercise type for patients with coronary artery disease.
Investigators
Borut Jug
Associate Professor
University Medical Centre Ljubljana
Eligibility Criteria
Inclusion Criteria
- •myocardium infarction 120 days prior to cardiac rehabilitation
Exclusion Criteria
- •contraindications for exercise training,
- •uncontrolled dysrhythmias,
- •uncontrolled heart failure (New York Heart Association (NYHA) stage IV),
- •intellectual development disorder,
- •pregnancy.
Outcomes
Primary Outcomes
Change of flow-mediated dilatation of the brachial artery, measured in %
Time Frame: 3 months
Secondary Outcomes
- Change of the arterial stiffness coefficient(3 months)
- Change of maximal oxygen uptake during exercise, measured in ml/kg/min(3 months)
- Change in IL-6, IL-8, IL-10, TNF-alpha and NT-proBNP levels, measured in ng/l(3 months)
- Change in osteopontin and D-dimer levels, measured in microg/l(3 months)
- Change in selectin and hsCRP, measured in mg/l(3 months)
- Change in hsTnI, CK MB, endocan, sST2, galectin-3, NGAL, CD40 ligand and BDNF, measured in ng/l(3 months)
- Change in copeptin levels, measured in pmol/l(3 months)
- Change of the heart rate variability(3 months)
- Change of the heart rate recovery(3 months)
- Change in health-related quality of life using SF-36 questionnaire, measured in points(3 months)
- Change in total cholesterol, LDL, HDL, triglycerides and glucose levels, measured in mmol/l(3 months)
- Change in overall haemostatic potential(3 months)
- Change in MR-proADM and MR-proANP, measured in nmol/l(3 months)
- Change in homoarginine, ADMA and SDMA levels, measured in micromol/l(3 months)
- Change in fibrinogen and Lp(a) levels, measured in mg/dl(3 months)
- Change in insuline level, measure in microIU/ml(3 months)