Hemodynamic Measurements During Liver Transplantation
- Conditions
- Liver Transplantation
- Registration Number
- NCT00682110
- Lead Sponsor
- Washington University School of Medicine
- Brief Summary
The purpose of the study is to determine if the less invasive monitors are as reliable for measuring heart function in patients undergoing liver transplantation as the more invasive pulmonary artery.
- Detailed Description
Pulmonary artery catheter (PAC)is considered the gold standard in monitoring of heart function during orthotopic liver transplantation (OLT). Placement of PAC is very invasive (it passes thorough the heart chambers and into the pulmonary artery) and its benefits on the outcomes have not been proven. This study compares two newer FDA approved much less invasive devices to the PAC. The two new devices assess the heart function based either on the peripheral arterial waveform alone (Vigileo, Edwards Lifesciences)or the combination of peripheral arterial waveform and chemical indicator dilution (LiDCO, Cambridge, UK).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- Patients over 18 years of age
- Scheduled for liver transplantation
- Patient undergoing vascular surgery where invasive arterial pressure is indicated (control subjects)
- We will exclude patients taking lithium based medication
- Patients who weigh less than 40 kg; AND
- Patients who are pregnant
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Agreement between cardiac output measurements obtained with PAC, Vigileo and LiDCO Specific phases of liver transplantation surgery
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Washington University School of Medicine
🇺🇸St. Louis, Missouri, United States