NCT03031405已完成不适用
The Effect of Oxytocin on the Acquisition and Consolidation of Trauma-Associated Memories: A Model to Understand the Development of Posttraumatic Stress Disorder
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 220
- 试验地点
- 1
- 主要终点
- Intrusive memories
研究概览
简要总结
The purpose of the study is to examine whether oxytocin and oxytocin receptor gene polymorphism affect the development of intrusive memories, a cardinal symptom of PTSD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 44 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •healthy female volunteers
- •German on a native level
排除标准
- •former or present disorder according to the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5)
- •any physical illnesses
- •any medication intake (except oral contraceptive)
- •history of traumatic experience, e.g. history of sexual abuse or rape
- •pregnancy or lactation period
- •follicular phase of menstrual cycle for all women not using oral contraceptives
研究组 & 干预措施
Oxytocin and trauma film paradigm
Experimental
干预措施: Oxytocin nasal spray (Drug)
Placebo and trauma film paradigm
Placebo Comparator
干预措施: Placebos (Drug)
结局指标
主要结局
Intrusive memories
时间窗: four consecutive days
Influence of oxytocin on the development of intrusive memories measured with an intrusion diary
次要结局
- Noradrenergic System (measured with salivary alpha-amylase - u/ml)(Day 1)
- Genetic polymorphism(four consecutive days)
- Hypothalamic-pituitary-adrenal (HPA) axis (measured with salivary cortisol - nmol/L)(Day 1)
研究者
Katharina Schultebraucks
PhD
Charite University, Berlin, Germany
研究点 (1)
Loading locations...
相似试验
已完成
不适用
The Effect of Oxytocin on the Consolidation of Trauma-Associated MemoriesIntrusive MemoriesPTSDNCT03875391Charite University, Berlin, Germany217
已完成
不适用
A clinical test to study Hormone(Oxytocin)level and OXTR gene changes in patients with and without persistent pain after surgery to deliver a baby(Caesarean delivery)CTRI/2020/04/024699Department of Anaesthesia University College of Medical Sciences GTB Hospital
已完成
2 期
Evaluation of Oxytocin,s effect in comparison with placebo on craving; withdrawal and stress response due to heroin.Condition 1: Withdrawal syndrome. Condition 2: Craving.Mental and behavioural disorders due to use of opioidsIRCT2015103024792N1Vice chancellor for research Kashan University of Medical Sciences50
已完成
不适用
The Modulatory Effect of Oxytocin on InteroceptionInteroceptionNCT03074409University of Electronic Science and Technology of China83
暂停
不适用
The Effect of Oxytocin Administration on Interpersonal Cooperation in Borderline Personality Disorder Patients and Healthy AdultsBorderline Personality DisorderNCT02225600Icahn School of Medicine at Mount Sinai40