The Modulatory Effect of Oxytocin on Interoception
概览
- 阶段
- 不适用
- 干预措施
- oxytocin
- 疾病 / 适应症
- Interoception
- 发起方
- University of Electronic Science and Technology of China
- 入组人数
- 83
- 试验地点
- 1
- 主要终点
- Heartbeat Detection (Interoception) Accuracy
- 状态
- 已完成
- 最后更新
- 6年前
概览
简要总结
This study is designed to investigate oxytocin's effects on interoception and whether these effects vary as a function of different emotional valence.
详细描述
The present study will use a double-blind, between-subject, placebo-controlled design to investigate the modulatory effect of oxytocin on interoception and whether this effect will vary as a function of emotional valence. In Experiment 1, subjects will perform a heartbeat detection task and the group differences between oxytocin and placebo groups of the interoceptive accuracy and neural activity in the core interoceptive network will be investigated. In Experiment 2, subjects will be asked to watch emotional faces while perform the heartbeat detection task. Investigators will examine whether oxytocin's effects on interoception will be varied as a function of different emotional valence.
研究者
Keith Kendrick
Professor
University of Electronic Science and Technology of China
入排标准
入选标准
- •Healthy subjects
排除标准
- •Subjects reported having any neurological problems, psychiatric illness or drug or alcohol abuse and none were currently taking any form of medication and had not drunk any caffeine-containing beverages on the day of the experiment.
研究组 & 干预措施
oxytocin
intranasal administration of oxytocin
干预措施: oxytocin
placebo
intranasal administration of the same ingredient except oxytocin
干预措施: placebo
结局指标
主要结局
Heartbeat Detection (Interoception) Accuracy
时间窗: 45 minutes after oxytocin/placebo treatment
heartbeat detection (interoception) accuracy is calculated by the following equation: 1/N ∑ (1 - (\|recorded heartbeats - counted heartbeats\|)/recorded heartbeats). N was the number of blocks for the heartbeat detection task.
Interoceptive Network Activity
时间窗: 45 minutes after oxytocin/placebo treatment
interoceptive network (including anterior insula and dorsal cingulate cortex) activity as measured by the functional MRI technique in the heartbeat detection task. In the heartbeat detection task participants were instructed to make a keypress each time they felt their heartbeat. The interoceptive network activity was indicated by the percentage of BOLD signal change. The value of the percentage of BOLD signal change indicates the level of a certain brain region activated (the involvement of a brain region in a specific cognitive process).