Effects of Oxytocin on Emotion Recognition and Response Inhibition
概览
- 阶段
- 2 期
- 干预措施
- Oxytocin
- 疾病 / 适应症
- The Impact of Oxytocin on Social Cognition
- 发起方
- RWTH Aachen University
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- BOLD response during emotion recognition in contrast with a corresponding control condition.
- 最后更新
- 11年前
概览
简要总结
The purpose of this study is to shed light on the basic neurobiological mechanisms which underlie social information processing in healthy men. More specifically, we intend to examine whether a person's social competence level is related to the patterns of neural activity and his visual search strategies during evaluation of social scenes. Furthermore, it will be assessed whether an oxytocin-driven increase in activity in brain areas relevant to the task will facilitate social information processing and thus enhance task performance. Additionally it will be examined whether oxytocin can facilitate response inhibition in an emotional context.
研究者
入排标准
入选标准
- •MRI- eligibility
- •Subject's ability to fully grasp the type, scope and individual consequences of the study
- •Willingness to participate in and comply with the study procedures as indicated by signing the dated informed consent form
排除标准
- •Left-handedness
- •Regular intake of medication
- •Hypersensitivity towards oxytocin or a chemically similar substance
- •Current or previous neurological or psychiatric disorder
- •Nose surgery or chronic sinus infection
- •Any somatic disorder that may interfere with the experimental procedures, affect the outcome measures or pose a risk for the participant during performance of the experiment
研究组 & 干预措施
Cross over Oxytocin and Placebo
fMRI measurement and blood examinations following 26 IU Oxytocin (Syntocinon) on day 1 and following placebo on day 14
干预措施: Oxytocin
Cross over Oxytocin and Placebo
fMRI measurement and blood examinations following 26 IU Oxytocin (Syntocinon) on day 1 and following placebo on day 14
干预措施: Placebo
Cross over Placebo and Oxytocin
fMRI measurement and blood examinations following placebo on day 1 and following 26 IU Oxytocin (Syntocinon) on day 14
干预措施: Oxytocin
Cross over Placebo and Oxytocin
fMRI measurement and blood examinations following placebo on day 1 and following 26 IU Oxytocin (Syntocinon) on day 14
干预措施: Placebo
结局指标
主要结局
BOLD response during emotion recognition in contrast with a corresponding control condition.
时间窗: (Day 1: oxytocin, Day: 14:placebo, or vice versa [counterbalanced])
In the Social Detection Task, subjects' brain activity when viewing social scenes will be compared to corresponding control scenes in which no people are shown. In the GoNoGo Task several emotional conditions will be compared to a neutral control condition.
BOLD response during response inhibition (Emotional Go/ Nogo) in contrast with a corresponding control condition.
时间窗: (Day 1: oxytocin, Day: 14:placebo, or vice versa [counterbalanced])
Brain activation during NoGo trials will be compared to brain activation during Go trials from the same emotional condition.
次要结局
- Total length of fixations on areas of interest (AOIs) assessed via eye-tracking((Day 1: oxytocin, Day: 14:placebo, or vice versa [counterbalanced]))
- Percentage of correct responses in an emotion recognition paradigm (Social Detection Task) and a response inhibition task (Emotional Go/Nogo).((Day 1: oxytocin, Day: 14:placebo, or vice versa [counterbalanced]))
- Serum levels of Oxytocin((Day 1: oxytocin, Day: 14:placebo, or vice versa [counterbalanced]))
- Serum levels of Cortisol((Day 1: oxytocin, Day: 14:placebo, or vice versa [counterbalanced]))
- Response time in an emotion recognition paradigm (Social Detection Task) and a response inhibition task (Emotional Go/Nogo).((Day 1: oxytocin, Day: 14:placebo, or vice versa [counterbalanced]))
- Serum levels of Prolaktin((Day 1: oxytocin, Day: 14:placebo, or vice versa [counterbalanced]))
- Number of fixations on areas of interest (AOIs) assessed via eye-tracking((Day 1: oxytocin, Day: 14:placebo, or vice versa [counterbalanced]))