Oxytocin and Emotion Processing

Phase 1

Completed

• Conditions: Healthy Males
• Interventions: Drug: Oxytocin

• Registration Number: NCT02156661
• Lead Sponsor: University Hospital, Bonn

Brief Summary

The purpose of this study is to determine whether oxytocin influences emotional processing and learning of emotional and social stimuli.

Detailed Description

An effect of OXT on emotion processing and anxiety has been broadly investigated in animal studies. However, in humans, effects seem more complex.

The rationale of the study is to examine direct effects of OXT to processing and learning of emotional and social values in humans.

Study Timeline

• Study Start: 2013-05
• Primary Completion: 2014-06
• Study Completion: 2014-06
• Study First Submitted: 2014-06-03
• Study First Submitted QC: 2014-06-04
• Study First Posted: 2014-06-05
• Status Verified: 2017-05
• Last Update Submitted: 2017-05-05
• Last Update Posted: 2017-05-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 97

Inclusion Criteria

• Healthy male volunteers

Exclusion Criteria

• Current or past psychiatric disease
• Current or past physical illness
• Psychoactive medication
• Tobacco smokers
• MRI contraindication

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Oxytocin	Oxytocin	Oxytocin: Syntocinon-Spray, Novartis intranasal administration, 24 IU oxytocin; ; 3 puffs per nostril, each with 4 IU OXT
Placebo	Oxytocin	Placebo nasal spray

Primary Outcome Measures

Name	Time	Method
Brain activity	During emotion processing	fMRI

Secondary Outcome Measures

Name	Time	Method
Psychophysiological response	During stimuli presentation	Skin conductance response