Oxytocin Effects on Self and Other Processing
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 44
- Locations
- 1
- Primary Endpoint
- Compared the indifference point between buy and sell conditions during the price phase and the specific brain region activation between oxytocin and placebo groups
Study Overview
Brief Summary
To determine whether the neuropeptide oxytocin (OXT) influences self-processing by investigating whether it increases the endowment effect in relation to both self and others.
Detailed Description
In a double-blind, between- subject placebo (PLC) controlled design, investigator aimed to measure the effect of intranasal OXT on the endowment effect. All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety before self-administration: Positive and Negative Affect Schedule (PANAS) , State-Trait Anxiety Inventory (STAI) , Beck Depression Inventory (BDI), self-esteem scale (SES). Subjects were asked to decide whether to buy or sell their own or others' (their mothers'/ fathers'/ classmate'/ strangers') possessions at various prices. Indifference point and brain activation were inluded into analysis as dependent variables.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 27 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •healthy subjects without past or current psychiatric or neurological disorders
Exclusion Criteria
- •history of head injury;
- •claustrophobia;
- •medical or psychiatric illness.
Arms & Interventions
Oxytocin
Oxytoxin nasal spray
Intervention: Oxytocin (Drug)
Placebo
Placebo nasal spray
Intervention: Placebo (Drug)
Outcomes
Primary Outcomes
Compared the indifference point between buy and sell conditions during the price phase and the specific brain region activation between oxytocin and placebo groups
Time Frame: 1 hour
Indifference point is the gap between willingness to accept and willingness to pay ;focus on the specfic brain region relasted to self-processing, such as medial prefrontal cortex, precuneus, posterior cingulate cortex, ventral striatum.
Secondary Outcomes
No secondary outcomes reported