NCT01363739Unknown不适用
Prospective Evaluation of -1498 c/t VEGF Polymorphism in the Prediction of Benefit From First-line Folfiri Plus Bevacizumab in Metastatic Colorectal Cancer Patients
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 265
- 试验地点
- 1
- 主要终点
- Progression-Free Survival
研究概览
简要总结
-1498C/T VEGF polymorphism, as suggested by a recent retrospective analysis, seems to have a role in predicting the efficacy of Bevacizumab plus FOLFIRI in first-line treatment of metastatic colorectal cancer patients. The present study aims to prospectively evaluate the predictive role of this polymorphism in metastatic colorectal patients receiving the same treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically confirmed colorectal adenocarcinoma;
- •Measurable metastatic disease according to RECIST criteria;
- •Patients receiving BV plus FOLFIRI as first-line treatment;
- •Written informed consent;
- •Availability of blood samples for genetic analysis.-
排除标准
- 未提供
结局指标
主要结局
Progression-Free Survival
Progression free survival (PFS) is defined as time from study entry until progression of disease (according to RECIST 1.1) or death from any cause. Patients who are alive without having progressed at the end of the study will be censored at their last radiological assessment
次要结局
- Response Rate
- Overal survival
研究者
研究点 (1)
Loading locations...
相似试验
Unknown
不适用
VEGF Gene Association With Response to Neovascular Age-related Macular Degeneration With Anti-VEGF AgentsMacular DegenerationNCT01655589Institute of Vision, Brasil74
已完成
不适用
Polymorphism Interaction to Predict Bevacizumab EfficacyMetastatic Breast CancerNCT01935102University of Pisa169
已完成
不适用
Relationship Between the VEGF Gene Polymorphism and Cardiometabolic Risk FactorsPolymorphism, Restriction Fragment LengthNCT04077554Poznan University of Medical Sciences400
Enrolling By Invitation
不适用
Pilot Study to Evaluate the Contribution of Gene Variants to Idiopathic UrolithiasisKidney StonesCalcium Oxalate UrolithiasisUrolithiasisNCT01127854Mayo Clinic2,900
进行中（未招募）
不适用
Pilot study of association of VEGF polymorphisms with clinical efficacy and tolerability of therapy in patients affected by exudative (neovascular) age-related macular degeneration. - DEGENEExudative and atrophic age-related macular degeneration.MedDRA version: 6.1Level: PTClassification code 10025409EUCTR2007-004487-53-ITAZIENDA OSPEDALIERA PISANA