Detection of calcitonin gene-related peptide (CGRP) in serum and tear fluid in headache associated with changes in CSF pressure or sinus vein thrombosis.

Recruiting

Conditions: G93.2
Other reaction to spinal and lumbar puncture
Other specified headache syndromes
I67.6
G97.1
G44.8
Benign intracranial hypertension
Nonpyogenic thrombosis of intracranial venous system

Registration Number: DRKS00025278

Lead Sponsor: eurologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 200

Inclusion Criteria

Inclusion Criteria for verum group

age over 18
german mother tongue
Headache associated with IIH or SIH or SVT
signed informed consent

Inclusion Criteria for controll group

age over 18
german mother tongue
max. of 2 days of not severe headache per month
no primary headache disorder (exception: episodic tension type headache)
signed informed consent

Exclusion Criteria

Exclusion Criteria for verum group

age < 18
other headache disorders (not episodic migraine or episodic tension type headache)
hypertension
CGRP (Receptor) antibodies in the last 3 months
severe psychiatric, endocrin
ological disorders, opththalmological disorders, contact lenses,
actual intake of triptans or other pain-medication in the last 48 hours before the visit (except vor SVT)

Exclusion Criteria controll group

Age < 18
BMI > 30 kg/m2
other headache disorders (not episodic migraine or episodic tension type headache)
hypertension
CGRP (Receptor) antibodies in the last 3 months
severe internal, neurological, psychiatric disorders,
actual intake of triptans or other pain-medication in the last 48 hours before the visit, Headache on the day of the examination

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantify trigeminal CGRP release in patients with headache under IIH, SVT, and SIH by measuring CGRP levels in tear fluid and plasma (and cerebrospinal fluid in IIH) compared with controll group.<br>

Secondary Outcome Measures

Name	Time	Method
-correlation of CGRP level with CSF opening pressure in patients<br>IIH and correlation of CGRP level in CSF with CGRP level in tear fluid and serum in patients.<br>Level in tear fluid and serum in patients.<br>- Correlation of CGRP level (plasma, CSF, tear fluid) before and<br>after puncture in IIH patients<br>- Analysis of localization and extent of SVT compared to CGRP-<br>levels in tear fluid and serum.