NL-OMON31434尚未招募不适用
Pilot Study assessing sildenafil effect on lung tumour blood flow - sildenafil tumour perfusion
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 10
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •1. Age > 18 years
- •2. WHO performance status 0-1
- •3. Adequate hematological, renal and hepatic functions
- •a. total bilirubin < 1.5 x UNL
- •b. ASAT/ALAT < 2 x UNL
- •c. alkaline phosphatase < 5 x UNL
- •d. creatinine < 130 mmol/L
- •4. Primary tumour size >=3cm
- •5. Written informed consent
排除标准
- •1. Concurrent NTG, ritonivir, azoles, other P450 inhibitors
- •2. Concurrent anti-hypertensive or nitrate medications
- •3. Hypersensitivity to sildenafil/component of formulation
- •4. Contrast allergy
- •5. Hypotension <90/50mmg
- •6. Other serious diseases such as heart failure, unstable angina, MI/CVA/serious arrhythmia within 6 months, diabetes
- •7. History of visual loss and genetic degenerative retinal disease e.g. retinitis pigmentosa
- •8. Pregnancy/lactation
研究者
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