Novel Biomarkers for Exposures in the Neonatal Intensive Care Unit
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Chemical Concentration in deciduous teeth
研究概览
简要总结
This study aims to identify early life exposures to metals and chemicals by measuring the concentration of metals and organic compounds in shed primary teeth. The researchers will also investigate associations between the presence of these chemicals in teeth and children's social, emotional, and neuro-development.
详细描述
Since children begin shedding their primary teeth around age 6, the investigators will enroll children who will be turning 6 in the next two years. First, the investigators will follow up with the children's development by conducting a battery of non-invasive neurodevelopmental tests. Also, the parents will be asked to complete a questionnaire called the Child Behavior Checklist, which assesses behavioral problems. Then, each child's parent will be asked to send the research team 2-3 teeth that their child has shed, or to send teeth as they are shed over the next three years. Dr. Stroustrup's collaborator, Dr. Manish Arora, will perform a temporal analysis of chemical distribution for each tooth to determine each child's environmental exposures during the perinatal and neonatal periods.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 4 Years 至 6 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •4-6 years of age in 2014 (six years of age by the end of 2016)
- •Cared for as a neonate in Mount Sinai's NICU
排除标准
- •Parent documented in Mount Sinai's database is no longer the legal guardian
- •Non-English-speaking parents
结局指标
主要结局
Chemical Concentration in deciduous teeth
时间窗: up to 5 years
Teeth will be analyzed by a dentist and researcher trained in laser ablation inductively coupled plasma mass spectroscopy technology
次要结局
- Wechsler Preschool and Primary Scale of Intelligence(up to 3 years)
- Child Behavior Checklist(up to 3 years)
- Development Neuropsychological Assessment (NEPSY)(up to 3 years)