Effectiveness of Binge Eating Disorder Treatments

Phase 4

Completed

• Conditions: Eating Disorders

• Registration Number: NCT00060762
• Lead Sponsor: Stanford University

Brief Summary

This study will evaluate the long-term effectiveness of interpersonal psychotherapy, behavioral weight loss interventions, and guided self help treatments in treating binge eating disorder (BED).

Detailed Description

BED is a serious condition that is associated with psychiatric comorbidity, psychosocial impairment, and obesity. Interpersonal psychotherapy (IPT), behavioral weight loss (BWL) interventions, and guided self help (GSH) treatments for BED have been evaluated, but the safest and most effective treatment has not yet been identified. This study will determine which of these three treatments is most effective in treating BED.

Participants are stratified by negative affect subtype and are randomly assigned for 6 months to one of three treatment groups: IPT, BWL, or GSH. IPT focuses on current interpersonal problems which are hypothesized to increase negative affect and lead to binge eating. BWL interventions involve the adoption of weight loss inducing behaviors. GSH is a shortened version of cognitive behavioral therapy that focuses directly on eating behavior. IPT and BWL patients have 20 treatment sessions; those receiving GSH have 10 sessions. Assessments are made pre-treatment, post-treatment, and at 6, 12, 18, and 24 months after treatment is complete.

Study Timeline

• Study Start: 2002-04
• Study First Submitted: 2003-05-12
• Study First Submitted QC: 2003-05-12
• Study First Posted: 2003-05-13
• Primary Completion: 2007-03
• Study Completion: 2007-03
• Status Verified: 2014-05
• Last Update Submitted: 2014-05-14
• Last Update Posted: 2014-05-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 205

Inclusion Criteria

• DSM-IV criteria for Binge Eating Disorder
• Body Mass Index (BMI) between 27 and 45

Exclusion criteria:

• Body Mass index > 45
• Current psychosis
• Current bipolar disorder
• Alcohol or drug dependence within last 6-months

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Binge eating	Pre-treatment, 6, 12, and 24-months	Rate of binge eating

Secondary Outcome Measures

Name	Time	Method
Eating disorder psychopathology	pre-treatment, 6, 12, 24 months	Assessed by the Eating Disorder Examination

Trial Locations

Locations (3)

W. Stewart Agras; 🇺🇸 Stanford, California, United States

Washington University School of Medicine; 🇺🇸 St. Louis, Missouri, United States

Rutgers University Eating Disorder Clinic; 🇺🇸 Piscataway, New Jersey, United States