Correlation Between the Visual Acuity & the OCT Pattern of Macular Edema Secondary to RVO

• Conditions: Retinal Vein Occlusion
• Interventions: Device: OCT

• Registration Number: NCT03489915
• Lead Sponsor: Assiut University

Brief Summary

Correlation between changes observed in OCT and VA in patients with retinal vein occlusion whether the patient's VA improves when macular edema improves in OCT or not ??

Detailed Description

Central retinal vein occlusion (CRVO) is a common retinal vascular disorder. Clinically, CRVO presents with variable visual loss; fundus may show retinal hemorrhages, dilated tortuous retinal veins, cotton-wool spots, macular edIn view of the devastating complications associated with the severe form of CRVO, number of classifications were described. All of classifications take into account the area of retinal capillary nonperfusion and development of neovascular complications.

CRVO can be divided into 2 clinical types, ischemic and nonischemic. In addition, a number of patients may have an intermediate presentation with variable clinical course. On initial presentation, it may be difficult to classify a given patient, since CRVO may change with time.

A number of clinical and ancillary investigative factors are taken into account for classifying CRVO:

Nonischemic CRVO is milder form of disease. It may present with good vision, few retinal hemorrhages and cotton-wool spots, no relative afferent pupillary defect, and good perfusion to the retina. Nonischemic CRVO may resolve fully with good visual outcome or may progress to the ischemic type.

Ischemic CRVO is the severe form of the disease. CRVO may present initially as the ischemic type, or it may progress from nonischemic. Usually, ischemic CRVO presents with severe visual loss, extensive retinal hemorrhages and cotton-wool spots, presence of relative afferent pupillary defect, poor perfusion to retina, and presence of severe electroretinographic changes. In addition, patients may end up with neovascular glaucoma and a painful blind eye.

Study Timeline

• Study First Submitted: 2018-03-23
• Status Verified: 2018-04
• Study First Submitted QC: 2018-04-04
• Last Update Submitted: 2018-04-04
• Study First Posted: 2018-04-06
• Last Update Posted: 2018-04-06
• Study Start: 2018-05-01
• Primary Completion: 2020-03-30
• Study Completion: 2020-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients with macular edema related to vein occlusion .
• Patient's Age above 18 years old .
• Patients able to sit on OCT device .

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Exclusion Criteria

• Significant cataract .
• Media opacities as vitreous haemorrhage .
• patients with macular edema related to CRVO treated by laser photocoagulation .
• patients with glaucoma .
• Patients with chronic uveitis.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with macular edema due to RVO	OCT	assessment of visual acuity using Landolt chart and follow up of macular edema using OCT

Primary Outcome Measures

Name	Time	Method
Macular edema assessment	5 minutes	Macular edema assessed by OCT in microns
Visual acuity assessment	5 minutes	Visual acuity assessment through Landolt chart

Secondary Outcome Measures

Name	Time	Method
Causes of non improvement of visual acuity in patients with resolving macular edema	5 minutes	To detect causes of visual non improvement with visual acuity measured through Landolt chart in patients with resolving macular edema measured by OCT device in microns