Dexamethasone Tolerability in the Treatment of Acute Asthma in Children
- Registration Number
- NCT00973687
- Lead Sponsor
- IWK Health Centre
- Brief Summary
The purpose of this study is to assess whether smaller volumes of oral dexamethasone result in better tolerability, specifically less vomiting, in pediatric patients during an acute asthma exacerbation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 430
Inclusion Criteria
- acute asthma exacerbation
- requiring oral systemic corticosteroids for management
Exclusion Criteria
- preference for pills over liquid formulation
- history of Nissen fundoplication surgery
- needed immediate airway intervention
- require oral medications to be given via a G or J tube
- if patient care would be compromised
- enrolled in the study on a previous visit.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 10 mg/mL Unsweetened Formulation Dexamethasone no prior vomiting 1 mg/mL Ora Sweet Formulation Ora Sweet no prior vomiting 1 mg/mL Ora Sweet Formulation Dexamethasone no prior vomiting 10 mg/mL Unsweetened with prior vomiting Dexamethasone with prior vomiting 1 mg/mL Ora Sweet with prior vomiting Ora Sweet with prior vomiting 1 mg/mL Ora Sweet with prior vomiting Dexamethasone with prior vomiting
- Primary Outcome Measures
Name Time Method The primary objective of this study was to assess whether smaller volumes of oral dexamethasone resulted in better tolerability, specifically less vomiting, in pediatric patients with an acute exacerbation of asthma. During Emergency Department visit
- Secondary Outcome Measures
Name Time Method To evaluate asthma symptom control post emergency room visit for acute asthma exacerbation. 7-14 days following emergency dept visit
Trial Locations
- Locations (1)
IWK Health Centre
🇨🇦Halifax, Nova Scotia, Canada