Hypofractionated Radiotherapy for Squamous Cell Carcinoma of the Head and Neck in Elderly Patients: A Prospective Phase II Clinical Study
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- PFS
研究概览
简要总结
Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumor, with 25% of HNSCC patients diagnosed at over 70 years of age. As the population ages, it is expected that by 2030, this proportion will exceed 60%. Elderly patients are gradually becoming the main population among head and neck cancer patients. Older patients often have a lower desire to seek medical treatment, leading to a higher number of late-stage diagnoses. Additionally, with declining physical function and multiple comorbidities, frequent hospital visits can be inconvenient, making them often unsuitable for aggressive surgery or comprehensive treatment.
In clinical practice, the commonly used conventional fractionated radiotherapy (66-70 Gy in 1.8-2.2 Gy per session over 30-33 sessions, completed in 6-7 weeks) is a time-consuming and intensive treatment method, often resulting in significant and prolonged acute and late toxicities. Hypofractionated radiotherapy (HFRT) significantly reduces the number of treatment sessions and shortens the treatment duration compared to conventional fractionation. Additionally, delivering higher doses can quickly and effectively reduce tumor burden by increasing the lethality to tumor cells.
Currently, there are few reports on HFRT for head and neck cancer patients abroad, and no reports on this treatment regimen for elderly HNSCC patients in China. In preliminary studies, our research group utilized a segmented hypofractionated regimen (66 Gy in 3.3 Gy per session for 20 sessions, treated for 2 weeks, followed by 1 week of rest, and then treated for another 2 weeks) to treat 12 HNSCC patients aged 77 to 97 years. The recent effective rate was 100%, with good treatment tolerance and no severe toxic reactions observed.
详细描述
This study aims to conduct a prospective study to evaluate the efficacy and safety of segmented hypofractionated radiotherapy in elderly patients with head and neck squamous cell carcinoma and to explore a radiotherapy fractionation scheme suitable for elderly HNSCC patients in China.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 65 years;
- •Patients with histologically or cytologically confirmed stage II-IVA head and neck squamous cell carcinoma (AJCC 8th edition), including oral cavity, oropharynx, hypopharynx, larynx, and cervical metastatic squamous carcinoma of unknown primary;
- •At least one measurable lesion;
- •No prior systemic antitumor treatment or locoregional therapy for head and neck squamous cell carcinoma;
- •ECOG performance status of 1-3;
- •Expected survival time of ≥ 3 months;
- •Patients assessed by the physician as unsuitable for surgical treatment and not candidates for radical radiotherapy;
- •Functional status of vital organs compatible with daily basic activities (excluding any blood components or cell growth factors within 14 days): adequate bone marrow reserve function: white blood cells (WBC) ≥ 2.0 × 10^9/L, neutrophil count (NEUT) ≥ 1.0 × 10^9/L, platelet count (PLT) ≥ 80 × 10^9/L, hemoglobin (Hb) ≥ 90 g/L;
- •Able and willing to comply with the study and follow-up procedures;
- •The subject voluntarily agrees to participate in this clinical study and signs the informed consent form, demonstrating good compliance and ability to cooperate with follow-up.
排除标准
- •Previously undergone radiotherapy for head and neck cancer;
- •Squamous cell carcinoma of other primary sites in the head and neck, such as paranasal sinuses, nasopharynx, glottic laryngeal cancer, skin, or salivary gland tissues;
- •Concurrent other antitumor therapies;
- •Neoadjuvant therapy;
- •Subjects who have experienced a severe infection within one month before enrollment, including but not limited to infections requiring hospitalization, bacteremia, severe pneumonia, etc.;
- •Subjects with any active infection or unexplained fever > 38.5°C occurring during the screening period or before the first dose;
- •Presence of severe cardiovascular diseases: Grade II or higher myocardial ischemia or myocardial infarction, poorly controlled arrhythmias (including QTc interval male ≥ 450 ms, female ≥ 470 ms); NYHA Class III-IV heart failure (according to the New York Heart Association classification, see Appendix 3), or echocardiogram indicating left ventricular ejection fraction (LVEF) < 50%;
- •History of other malignancies within the past five years (except for completely treated in situ cervical cancer or basal cell carcinoma or squamous cell carcinoma of the skin);
- •History of substance abuse involving psychiatric drugs that cannot be discontinued or presence of mental disorders.
研究组 & 干预措施
hypofractionated radiation
The hypofractionated radiotherapy regimen specified in this study is as follows:
Radiotherapy: The positioning is referenced from the guidelines of the Radiation Oncology Department of the Chinese Academy of Medical Sciences Cancer Hospital. The specific contouring and target area definitions are provided in the main text. The recommended radiation doses and fractionation methods are:
95% PGTVp: 33 Gy in 3.3 Gy per session for 10 sessions, and 95% PTV1: 25 Gy in 1.5 Gy per session for 10 sessions, with an interval of 1-2 weeks, for a total of 2 cycles.
干预措施: Hypofractionated Radiation Therapy (Radiation)
结局指标
主要结局
PFS
时间窗: 6 months
Progression-Free Survival, is defined as the time from random assignment to documented local or regional relapse, distant metastasis, or death from any cause, whichever occurred first after 6 months of treatment.
次要结局
- LRC(18 months)
- OS(18 months)
- DMFS(18 months)
- PFS(18 months)