Effects and Neural Mechanisms of Training Involving Rhythmic Auditory Stimulation on Upper-limb Movements in Patients With Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 72
- 主要终点
- The box and block test (BBT)
研究概览
简要总结
Introduction Bradykinesia (i.e., slow movements) is one of the most prominent symptoms of Parkinson's disease (PD) and has a negative impact on quality of life. Rhythmic auditory stimulation (RAS), a widely used and promising treatment technique, has been shown to effectively improve gait speed in PD patients. However, only few studies have explored effects and neural mechanisms of RAS on upper-limb movements. We will conduct two studies to investigate effects and mechanisms of RAS on upper-limb movements in PD patients. The purpose of this study is to examine effects and neural mechanisms of upper-limb movement training involving RAS in PD patients.
Methods This study will recruit patients with PD and healthy controls. This study will randomly assign PD patients into two groups: the PD-RAS group and the PD-noRAS group, and healthy controls into the HC-RAS group and the HC-noRAS group. A 7-day upper-limb training involving RAS (for the PD-RAS group and the HC-RAS group) or without RAS (for the PD-noRAS group and the HC-noRAS group) will be provided. EEG and behavioral assessments will be conducted before and after the first day of training, and after the seven-day training program. Two-way repeated measures analysis of variance will be performed to investigate the group and time effects on upper-limb function and neural activity.
Study significance The training program will serve as a reference for clinical practitioners who are interested in using RAS in clinical training for PD patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •(a) idiopathic PD diagnosed by a neurologist based on the Movement Disorders Society clinical diagnostic criteria;
- •(b) the Hoehn and Yahr stage is 2 or 3, meaning that bilateral movement problems or combination with mild postural instability;
- •(c) a score of Montreal Cognitive Assessment (MoCA) is equal to or higher than 21 to ensure that they understand experimental instructions;
- •(d) a score of Edinburgh Handedness Inventory is above 60 to ensure that they are right-handed;
- •(e) types and doses of medications remain unchanged in the past month right before participation.
- •Age- and sex-matched healthy controls who filled the criteria (c) and (d) will be recruited from communities.
排除标准
- •the presence of medical conditions or diseases that may affect hand movements, vision, or hearing based on self-report.
结局指标
主要结局
The box and block test (BBT)
时间窗: Assessments will be performed after the seven-day training program.
The BBT is used to measure gross manual dexterity as well as upper-limb movement speed.
The nine hole peg test (NHPT)
时间窗: Assessments will be performed after the seven-day training program.
The NHPT is a widely used measure of hand dexterity in a broad range of ages and populations.
Electroencephalography (EEG)
时间窗: Assessments will be performed after the seven-day training program.
The power (unit:Watt) of EEG will be calculated.
次要结局
- The Jebsen Hand Function Test (JHFT)(Assessments will be performed after the 7-day training.)
- Ruler Drop Test (RDT)(Assessments will be performed after the 7-day training.)
研究者
FAN Wei
PhD Student
The Hong Kong Polytechnic University