Reflex Excitability in Post-stroke Stiff-Knee Gait

Not Applicable

Recruiting

• Conditions: Chronic Stroke; Gait, Hemiplegic; Stroke; Gait Disorder, Sensorimotor; Gait Disorders, Neurologic; Walking, Difficulty; Gait, Spastic
• Interventions: Other: Peripheral nerve stimulation; Device: Commercial knee brace

• Registration Number: NCT04947865
• Lead Sponsor: MetroHealth Medical Center

Brief Summary

The purpose of this study is to examine the reflex excitability of the rectus femoris in individuals with and without post-stroke Stiff-Knee gait. We use electrical stimulation of the peripheral nerve innervating the rectus femoris for a well-controlled reflex stimulus. We are investigating whether reflex excitability of the rectus femoris correlates with gait kinematics.

Detailed Description

The purpose of this study is to investigate the role of hyperreflexia in post-stroke Stiff-Knee gait function. In one aim,

Study Timeline

• Study Start: 2021-06-11
• Study First Submitted: 2021-06-11
• Study First Submitted QC: 2021-06-23
• Study First Posted: 2021-07-01
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-05
• Last Update Posted: 2024-04-08
• Primary Completion: 2025-06-11
• Study Completion: 2026-06-11

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Post-stroke Stiff-Knee Gait Participants	Peripheral nerve stimulation	Individuals with post-stroke Stiff-Knee gait
Healthy Individuals	Peripheral nerve stimulation	Healthy Individuals
Healthy Individuals	Commercial knee brace	Healthy Individuals

Primary Outcome Measures

Name	Time	Method
Surface electromyographic recording of leg muscles during different conditions	1 hour	Recording electrical activity of leg muscles during walking in response to peripheral nerve stimulation

Secondary Outcome Measures

Name	Time	Method
Circumduction measure	1 hour	Hip abduction joint motion measured with motion capture

Trial Locations

Locations (1)

MetroHealth Medical Center; 🇺🇸 Cleveland, Ohio, United States