The Study of Etiology, Epidemiology and Prognostic Factors of Acute Kidney Injury
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Renal Failure
- Sponsor
- Huashan Hospital
- Enrollment
- 651
- Locations
- 1
- Primary Endpoint
- renal function survival rate days in the hospital days in the ICU
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
- To investigate the etiology, epidemiology and prognostic factors of acute kidney injury.
- To find out risk factors that relate with the prognosis of acute kidney injury,focusing on inflammation, oxidative stress and nutritional status.
- To study on the relationship between gene polymorphism and prognosis of acute kidney injury.
Detailed Description
1. to investigate the relationship between preexisting malnutrition and adverse outcomes in patients with AKI - Several nutritional assessment methods such as anthropometric, clinical and biochemical evaluations have been used; however, no single indicator is considered to be a "gold standard." 2. to evaluate the association of serum nutritional variables and prognosis of acute kidney injury 3. Given the different half-lives of serum nutritional markers, we hypothesized that the utility of serum nutritional variables as prognostic predictors may differ in early death (\<7 days) and late death (\>7 days, \<28 days) patients.
Investigators
Feng Ding,MD
professor
Huashan Hospital
Eligibility Criteria
Inclusion Criteria
- •age \>=16 years and \<= 88 years
- •clinically diagnosed with acute kidney injury, according RIFLE or KDIGO criteria.
Exclusion Criteria
- •acute Renal Failure occurring in the setting of burns, obstructive uropathy, allergic interstitial nephritis, acute or rapidly progressive glomerulonephritis, vasculitis, hemolytic-uremic syndrome, thrombotic thrombocytopenic purpura (TTP), malignant hypertension, scleroderma renal crisis, atheroembolism, functional or surgical nephrectomy, hepatorenal syndrome, cyclosporin or tacrolimus nephrotoxicity
- •Do Not Resuscitate (DNR) status
- •subjects enrolled in another clinical trial that could affect the outcome of this study protocol
Outcomes
Primary Outcomes
renal function survival rate days in the hospital days in the ICU
Time Frame: discharg from hospital, 28days,90days