Etiology, Epidemiology and Prognostics of Acute Kidney Injury (AKI)

Completed

• Conditions: Renal Failure; Nutrition Disorders

• Registration Number: NCT00953992
• Lead Sponsor: Huashan Hospital

Brief Summary

* To investigate the etiology, epidemiology and prognostic factors of acute kidney injury.

* To find out risk factors that relate with the prognosis of acute kidney injury,focusing on inflammation, oxidative stress and nutritional status.

* To study on the relationship between gene polymorphism and prognosis of acute kidney injury.

Detailed Description

1. to investigate the relationship between preexisting malnutrition and adverse outcomes in patients with AKI

- Several nutritional assessment methods such as anthropometric, clinical and biochemical evaluations have been used; however, no single indicator is considered to be a "gold standard."

2. to evaluate the association of serum nutritional variables and prognosis of acute kidney injury

3. Given the different half-lives of serum nutritional markers, we hypothesized that the utility of serum nutritional variables as prognostic predictors may differ in early death (\<7 days) and late death (\>7 days, \<28 days) patients.

Study Timeline

• Study Start: 2009-04
• Study First Submitted: 2009-08-05
• Study First Submitted QC: 2009-08-05
• Study First Posted: 2009-08-06
• Primary Completion: 2018-12
• Study Completion: 2019-05
• Status Verified: 2019-08
• Last Update Submitted: 2019-08-21
• Last Update Posted: 2019-08-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 651

Inclusion Criteria

• age >=16 years and <= 88 years
• clinically diagnosed with acute kidney injury, according RIFLE or KDIGO criteria.

Exclusion Criteria

• acute Renal Failure occurring in the setting of burns, obstructive uropathy, allergic interstitial nephritis, acute or rapidly progressive glomerulonephritis, vasculitis, hemolytic-uremic syndrome, thrombotic thrombocytopenic purpura (TTP), malignant hypertension, scleroderma renal crisis, atheroembolism, functional or surgical nephrectomy, hepatorenal syndrome, cyclosporin or tacrolimus nephrotoxicity
• Do Not Resuscitate (DNR) status
• subjects enrolled in another clinical trial that could affect the outcome of this study protocol

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
renal function survival rate days in the hospital days in the ICU	discharg from hospital, 28days,90days

Trial Locations

Locations (1)

Shanghai Ninth People's Hospital; 🇨🇳 Shanghai, China