NCT02967263招募中不适用
The Study of Etiology, Epidemiology and Prognostic Factors of Acute Kidney Injury
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University1 个研究点 分布在 1 个国家目标入组 713 人开始时间: 2015年1月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 713
- 试验地点
- 1
- 主要终点
- all-cause mortality
研究概览
简要总结
- To investigate the etiology and epidemiology of acute kidney injury (AKI).
- To find out risk factors associated with the occurence of AKI.
- To find out risk factors related to the prognosis of AKI,focusing on uremic toxins, inflammation, oxidative stress and nutritional status.
- To study on the relationship between gene polymorphism and prognosis of acute kidney injury.
详细描述
- To investigate the relationship between preexisting protein-energy wasting (PEW) and adverse outcomes in patients with AKI.
- To evaluate the association of serum nutritional variables and prognosis of AKI.
- Given the different half-lives of serum nutritional markers, we hypothesized that the utility of serum nutritional variables as prognostic predictors may differ in early death (<7 days) and late death (>7 days, <28 days) patients.
- To investigate the various kinds of uremic toxins in AKI, furthermore, to evaluate the relationship between uremic toxins, especially protein bound toxins, and short- or long-term mortality in AKI patients.
- To investigate the mineral bone disorders in AKI,and to evaluate whether these markers would role as prognostic predictors of AKI.
- Several risk factors of mortality in AKI,such as markers of PEW, inflammation and serum creatinine,have been used; however, no single indicator is considered to be a "gold standard."
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age >=18 years and <= 88 years
- •clinically diagnosed with acute kidney injury, according KDIGO criteria.
排除标准
- •preexisting chronic kidney failure (defined as an eGFR <60 ml/min per 1.73 m2)
- •post-renal obstruction or rapid progressive glomerulonephritis as the main cause of AKI
- •known acute renal dysfunction
- •hospital stays <24 hours
- •malignancy
结局指标
主要结局
all-cause mortality
时间窗: 90 days
次要结局
- renal function survival rate(90 days)
- days in hospital(90 days)
研究者
Ding Feng
professor
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
研究点 (1)
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