Randomized controlled trial testing the effect of cotrimoxazole prophylaxis on morbidity and mortality outcomes in breastfed HIV-exposed uninfected infants

niversity of KwaZulu Natal0 个研究点目标入组 1,298 人开始时间: 2013年8月21日最近更新: 2023年5月29日

适应症

试验速览

暂无简介。

•Infant born to a woman with confirmed HIV infection;
•Written informed consent to enroll infant into study obtained from mother;
•Infant age 6 weeks (between day 35-49) at study entry;
•Infant should be breastfeeding at time of screening and should be planning to breastfeed for at least 6 months;
•HIV-negative from a screening test performed prior to study entry;
•Mother (or infant) should be receiving PMTCT regimen or mother should be receiving lifelong ART;
•Singleton birth;
•Birth weight >2000g;
•Infant has not had any illness and has not received prior antibiotics or traditional medications;

•Indeterminate HIV test result at screening;
•Receipt of antibiotics or traditional medications prior to study entry;
•A known requirement for CTX prophylaxis prior to study entry;
•A known contra-indication for CTX prophylaxis prior to study entry;
•Infants with any major serious illness (eg., heart, liver, kidney disease) or congenital malformation;

发起方

niversity of KwaZulu Natal