Epidemiology of Risk Factors for Hospital-acquired Pneumonia in ICU Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Ventilator-Associated Pneumonia
- Sponsor
- University Hospital Olomouc
- Enrollment
- 310
- Primary Endpoint
- 30-day mortality (non modifiable HAP risk factor)
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
A retrospective, observational study compiled data from all consecutively admitted patients older than 18 years at ICU University Hospital in Olomouc in the period from 1 January 2011 to 31 December 2015 who fulfilled the criteria of HAP. The aim was to determine the severity of the specific risk factors of early and late HAP. Risk factors were divided into factors from the patient and from the hospitalization. Furthermore, an assessment of their relationship to mortality.
Detailed Description
The primary outcome was to evaluate the relationship between risk factors and the development of early/late onset HAP. Another outcome was assessed to evaluate the relation of risk factors early/late onset HAP and mortality. The crucial time for evaluating the presence of risk factors was their presence from hospital admission to the moment of fulfilling the criteria for pneumonia. Risk factors were divided into two groups, on factors of the patient (uncontrollable) and by the hospitalization (controllable). Factors of the patient were: gender (male/female), age at enrollment (years), Acute Physiology and Chronic Health Evaluation II (APACHE II) score, multi-organ failure presence (MOF), hypertension, ischemic heart disease (IHD) chronic renal insufficiency (CRI), continual use of renal replacement therapy (CRRT), acute renal insufficiency (ARI), diabetes mellitus (DM), Chronical Obstructive Pulmonary Disease (COPD), immunosuppression or leukopenia \<1.5x109/l, impaired consciousness with Glasgow coma scale (GCS) \<8 tracheotomy, head trauma/neurosurgery, abdominal surgery-thoracotomy. Side factors hospitalization were: aspiration into the lungs, urgent intubation, reintubated, sedation, bronchoscopy, nasogastric intubation, enteral feeding continuously/intermittently intolerance of enteral nutrition, physiotherapy, repeated transport of the patient from the ICU, length of hospital stay, length of mechanical ventilation, 30-day mortality.
Investigators
Radovan Uvizl
MUDr., Ph.D.
University Hospital Olomouc
Eligibility Criteria
Inclusion Criteria
- •Hospital-Acquired Pneumonia
- •Intensive Care patient
- •X-ray signs of pneumonia
Exclusion Criteria
- •Age less than 18 years
- •Negative culture findings in the airways
- •Low quantity of culture findings
Outcomes
Primary Outcomes
30-day mortality (non modifiable HAP risk factor)
Time Frame: 30 days
Yes/No assessment
Secondary Outcomes
- Duration of mechanical ventilation before onset of HAP (non modifiable HAP risk factor)(7 days)
- Nasogastric intubation before onset of HAP (non modifiable HAP risk factor)(7 days)
- Duration of hospital stay before onset of HAP (non modifiable HAP risk factor)(7 days)
- Implementation of physiotherapy before onset of HAP (non modifiable HAP risk factor)(7 days)
- Urgent tracheal intubation before onset of HAP (non modifiable HAP risk factor)(7 days)
- Tracheal reintubation before onset of HAP (non modifiable HAP risk factor)(7 days)
- Immunosuppression or leukopenia less than 1.5x10 9/L before onset of HAP (modifiable HAP risk factor)(7 days)
- Chronic renal insufficiency before onset of HAP (modifiable HAP risk factor)(7 days)
- Repeated transport of the patient from the ICU (non modifiable HAP risk factor)(30 days)
- Condition after head trauma or neurosurgery before onset of HAP (modifiable HAP risk factor)(7 days)
- Intolerance of enteral nutrition before onset of HAP (non modifiable HAP risk factor)(7 days)
- Bronchoscopy before onset of HAP (non modifiable HAP risk factor)(7 days)
- Aspiration into the lungs before onset of HAP (non modifiable HAP risk factor)(7 days)
- Sedation administration before onset of HAP (non modifiable HAP risk factor)(7 days)
- Condition after abdominal surgery or thoracotomy before onset of HAP (modifiable HAP risk factor)(7 days)
- Condition after tracheotomy before onset of HAP (modifiable HAP risk factor)(7 days)
- Acute renal insufficiency without renal replacement therapy before onset of HAP (modifiable HAP risk factor)(7 days)
- Ischemic heart disease before onset of HAP (modifiable HAP risk factor)(7 days)
- Hypertension before onset of HAP (modifiable HAP risk factor)(7 days)
- Multi-organ failure before onset of HAP (modifiable HAP risk factor)(7 days)
- Impaired consciousness with Glasgow coma scale low than 8 before onset of HAP (modifiable HAP risk factor)(7 days)
- Diabetes mellitus before onset of HAP (modifiable HAP risk factor)(7 days)
- Chronical Obstructive Pulmonary Disease before onset of HAP (modifiable HAP risk factor)(7 days)
- Acute renal insufficiency with renal replacement therapy before onset of HAP (modifiable HAP risk factor)(7 days)