Effect of moderate wine consumption on the clinical symptoms of patients with inflammatory bowel disease
Not Applicable
Completed
- Conditions
- lcerative colitisDigestive SystemUlcerative colitis
- Registration Number
- ISRCTN11169656
- Lead Sponsor
- Institute of Food Science Research
- Brief Summary
2022 Results article in https://doi.org/10.1002/mnfr.202101073 (added 14/06/2022)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
Patients diagnosed with mild or moderate ulcerative colitis
Exclusion Criteria
1. Antibiotic intake up to 6 months before the study
3. Type I diabetes, endocrine and gastrointestinal disorders
4. Addiction to drugs or alcohol
5. Restrictive diets (vegetarians, vegans)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Markers of ulcerative colitis such as fecal calprotectin, iron, ferritin, C-reactive protein and white and blood cells measured by routine blood tests at initial and end treatment point (4 weeks)
- Secondary Outcome Measures
Name Time Method <br> 1. Quality of life measured by quality of life questionnaires (IBDQ-32) at initial and end treatment point (4 weeks)<br> 2. Microbial phenolic metabolites in faeces and urine measured by ultra-high-performance liquid chromatography–electrospray ionization–?tandem mass spectrometry (UHPLC-ESI-MS/MS) at initial and end treatment point (4 weeks)<br> 3. Short and medium-chain fatty acids in faeces measured by solid-phase microextraction gas chromatography-mass spectrometry (SPME-GC-MS) at initial and end treatment point (4 weeks)<br> 4. Composition, abundance and diversity of the faecal microbiota measured by sequencing the V3-V4 region of ribosomal DNA from fecal samples and metagenomic analysis at initial and end treatment point (4 weeks)<br>