Effects of Alcoholic Beverages in Pro-inflammatory and Antioxidant Profile After an Oral Fat Diet

Not Applicable

Completed

• Conditions: Alcohol Consumption
• Interventions: Other: Oral fat diet plus water with sugar; Other: Oral fat diet plus alcoholic beverages

• Registration Number: NCT02033174
• Lead Sponsor: Instituto de Investigación Sanitaria Gregorio Marañón

Brief Summary

Hypothesis: Red wine intake but not other alcoholic beverages together with a fat diet will decrease inflammatory factors and lipid peroxidation and decrease antioxidant capacity in healthy people after a five days period.

Detailed Description

Not available

Study Timeline

• Study Start: 2001-01
• Primary Completion: 2001-07
• Study Completion: 2001-07
• Study First Submitted: 2014-01-09
• Study First Submitted QC: 2014-01-09
• Study First Posted: 2014-01-10
• Results First Submitted: 2016-02-28
• Results First Submitted QC: 2016-09-06
• Results First Posted: 2016-10-26
• Status Verified: 2017-01
• Last Update Submitted: 2017-01-23
• Last Update Posted: 2017-03-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Healthy volunteers

Exclusion Criteria

• Individuals with a plasma cholesterol level > 220 mg/dl
• Smokers

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Sugar water first, then alcohol	Oral fat diet plus alcoholic beverages	8 participants have received oral fat diet plus water with sugar (equivalent caloric intakes as sugar with water in the control group). Then they receive the same oral fat-enriched diet (1486 kcal/m2) with 654 kcal/m2 (44%) as fat and a daily total amount of 16 g/m2 of alcohol, of different beverages (red wine, vodka, brandy or rum)
Alcohol first then sugar water	Oral fat diet plus alcoholic beverages	8 participants have received oral fat diet plus alcoholic beverages (a daily total amount of 16 g/m2 of alcohol, of different beverages : red wine, vodka, brandy or rum). Then they receive the same oral fat-enriched diet (1486 kcal/m2) with 654 kcal/m2 (44%) as fat and water with sugar (equivalent caloric intakes as sugar with water in the control group).
Sugar water first, then alcohol	Oral fat diet plus water with sugar	8 participants have received oral fat diet plus water with sugar (equivalent caloric intakes as sugar with water in the control group). Then they receive the same oral fat-enriched diet (1486 kcal/m2) with 654 kcal/m2 (44%) as fat and a daily total amount of 16 g/m2 of alcohol, of different beverages (red wine, vodka, brandy or rum)
Alcohol first then sugar water	Oral fat diet plus water with sugar	8 participants have received oral fat diet plus alcoholic beverages (a daily total amount of 16 g/m2 of alcohol, of different beverages : red wine, vodka, brandy or rum). Then they receive the same oral fat-enriched diet (1486 kcal/m2) with 654 kcal/m2 (44%) as fat and water with sugar (equivalent caloric intakes as sugar with water in the control group).

Primary Outcome Measures

Name	Time	Method
Change From Baseline in Concentrations of Antioxidant Profile After Red Wine Intake	Baseline and 5 days	In order to determine total antioxidant capacity a quantitative immunoassay using commercial kits (R\&D Systems, Inc. Minneapolis, USA) was conducted.

Trial Locations

Locations (1)

IiSGM; 🇪🇸 Madrid, Spain