Red wine polyphenols improve cardiometabolic risk in obese subjects by alleviating inflammation and microvascular dysfunctio

Completed

• Conditions: microvascular dysfunction; small vessel disease; 10011082; 10018424; 10003216

• Registration Number: NL-OMON39376
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Obese (BMI *30)
Age 18-70 years
Caucasian

Exclusion Criteria

cardiovascular disease
diabetes mellitus
recent history (<12 months) of high alcohol use > 4 U/day
use of medication potentially affection insulin sensitivity or microvasculair function
pregnancy
smoking

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>insulin sensitivity will be assessed during a hyperinsulinemic-euglycemic<br /><br>clamp.<br /><br>Skeletal muscle perfusion measured by contrast-enhanced ultrasonography before<br /><br>and during hyperinsulinemia/meal test.<br /><br>skin microvascular function (capillary microscopy and laser-doppler fluxmetry<br /><br>with iontophoresis)<br /><br>trancutaneous quadriceps muscle biopsy . Using Western blotting,<br /><br>phosphorylation of relevant molecules in the insulin signaling cascade will be<br /><br>assessed. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>24-hr ambulant blood pressure measurement<br /><br>markers of low-grade inflammation (hsCRP, fibrinogen, IL-6, TNF-alpha) and<br /><br>adipocytokines (circulating whole-adiponectin, leptin).</p><br>