Characterization of nociceptive perturbation and threshold tracking methods

Completed

• Conditions: chronic pain development; chronic pain

• Registration Number: NL-OMON39755
• Lead Sponsor: MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 165

Inclusion Criteria

18 years and older, legally competent, able to communicate, cognitively competent, informed consent.

Exclusion Criteria

pregnany, diabetes, MS, HIV/AIDS, not able to deal with used research methods, no compliance of instructions, loss of somatosensory function, deviating perception of pain, prolonged pain during the last three months, momentary pain-complaints, fatigue, fibromyalgia.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main parameters are:<br /><br>Experiment 1: Estimation method (ascending method or random stimulus method).<br /><br>Experiment 2: Perturbation method (Perturbation temperature).<br /><br>Experiment 3: Number of nociceptive thresholds.<br /><br>Experiment 4: Stimulus settings (number of pulses, inter-pulse interval, pulse<br /><br>width).<br /><br>Experiment 5: Temporal nociceptive perturbations.<br /><br>Experiment 6: Multilevel nociceptive perturbations.<br /><br><br /><br>The outcome measures are the estimated thresholds determined via logistic<br /><br>regression analysis over time. Moreover, the ratio between felt and not felt<br /><br>stimuli will be measured in the experiment 1.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>na</p><br>