eurological sequelae and changes in nociception after severe sepsis or septic shock

Recruiting

• Conditions: Septic shock; A41; R57.2; K72.7; Other sepsis

• Registration Number: DRKS00000735
• Lead Sponsor: Integriertes Forschungs- und Behandlungszentrum (IFB) Sepsis und Sepsisfolgen: Center for Sepsis Control and Care (CSCC); Universitätsklinikum Jena

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-03-21
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Common inclusion criteria (all participants):
Minimum age: 18; informed consent, sufficient skills in German language;
Sepsis specific: Maximum age: 85, survivors of severe sepsis/ septic shock; duration of mechanical ventilation = 3 days in ICU;
non septic ICU patients: Maximum age: 85;duration of mechanical ventilation = 3 days in ICU;
HE sepcific: Maximum age: 65; confirmed diagnosis of liver failure (sonographic, CT, histological); HE-grade 0-2,
Control specific: Maximum Age for neurological examinations: 65 and 85 years for pain examinations

Exclusion Criteria

common exclusion criteria (for all participants):
Participation in a different study; confirmed diagnosis of dementia or other severe neurological disorder (epilepsy included); seizure, confirmed septic shock or severe sepsis in anamnesis; recent drug abuse and/ or alcohol intoxication
sepsis specific: medication with analgetics; Amputation of upper limbs; confirmed chronic or other neuropathic pain disorder;
additionally for neurological examinations (25 patients): Medication with neuroleptics, sedatives, antidepressants, Amaurosis
non-septic ICU patients: ICU stay due to sepsis or septic shock; medication with analgetics; Amputation of upper limbs; confirmed chronic or other neuropathic pain disorder;
HE-specific: Medication with neuroleptics, sedatives, antidepressants, Amaurosis; life expectancy < 1 year; spontaneous bacterial peritonitis; actual delir and/ or deprivation; liver transplantation
control specific: medication with analgetics, amputation of the upper limbs; confirmed confirmed chronic or other neuropathic pain disorder; medication with neuroleptics, sedatives, antidepressants, Amaurosis;
MEG and MRI-sepcific: pace maker and other magnetic implants; claustrophobics; pregnancy

Study & Design

• Study Type: observational
• Study Design: Not specified