Nefopam as a Multimodal Analgesia for Thoracic Surgery
- Registration Number
- NCT05173337
- Lead Sponsor
- Kangbuk Samsung Hospital
- Brief Summary
Acute postoperative pain after video-assisted thoracoscopic surgery is very severe. Because pain after thoracic surgery prevents early recovery, and increases postoperative complications, its is important to prevent pain after video-assisted thoracoscopic surgery. In the present study, we will evaluate whether nefopam reduces pain after video-assisted thoracoscopic surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 46
- patient scheduled for elective video-assisted thoracoscopic surgery
- American Society of Anesthesiologists physical grade I, II, III
- patient aged from 18 years old
- history of allergy in nonsteroidal anti-inflammatory drugs, or nefopam
- renal insufficiency
- liver insufficiency
- myocardial infarction
- glaucoma
- pregnant and lactating women at the time of surgery
- patient who did not consent to the use of patient-controlled analgesia
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description nefopam group Nefopam Intravenous nefopam 20 mg will be administered twice, immediately after induction of anesthesia and at the end of surgery.
- Primary Outcome Measures
Name Time Method Pain after 12 hour of surgery 12 hours after surgery. Acute postoperative pain will be assessed using numerical rating scale from 0 (no pain) to 10 (worst pain ever).
Pain after 6 hour of surgery 6 hours hours after surgery. Acute postoperative pain will be assessed using numerical rating scale from 0 (no pain) to 10 (worst pain ever).
Pain after 1 hour of surgery 1 hour after surgery. Acute postoperative pain will be assessed using numerical rating scale from 0 (no pain) to 10 (worst pain ever).
Pain after 24 hour of surgery 24 hours after surgery. Acute postoperative pain will be assessed using numerical rating scale from 0 (no pain) to 10 (worst pain ever).
- Secondary Outcome Measures
Name Time Method Rescue analgesics 24 hours after surgery. Additional analgesic use during postoperative period.
Patient-controlled analgesia use 24 hours after surgery Fentanyl consumption administered thorough the patient-controlled analgesia machine.
Trial Locations
- Locations (1)
Eunah Cho
🇰🇷Seoul, Korea, Republic of