Nefopam for Post Video-Assisted Thoracoscopic Lobectomy
- Registration Number
- NCT04241640
- Lead Sponsor
- Mahidol University
- Brief Summary
Video-assisted thoracoscopic (VATs) lobectomy is mild to moderately pain procedure. For conventional thoracotomy, there are many invasive pain control such as epidural analgesia, paravertebral block. However, for VATs, the invasive pain control somehow are too invasive. Nefopam is non-opioid painkilling medication, Serotonin, norepinephrine, dopamine reuptake inhibitor. Many study were demonstrated positive outcome of nefopam usage in many operation such as abdominal surgery, laparocopic surgery, orthopedic surgery. Nevertheless, nefopam for VATs is not well studied yet.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 72
- Schedule to video-assisted thoracoscopic surgery : VATs lobectomy
- Can operate a patient-controlled analgesia (PCA) device
- No contraindication for nefopam
- Epilepsy, on monoamine oxidase (MAO) inhibitors, glaucoma
- Creatinine clearance < 60 ml/min
- Liver disease: child-pugh score B or C
- Allergy to nefopam
- Chronic opioid use
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Nefopam group[ Nefopam 20 MG/ML - placebo group Placebo -
- Primary Outcome Measures
Name Time Method morphine consumption in first 24 hours post-operative 24 hours morphine consumption record from patient-controlled analgesia machine in 24 hours post-operative
- Secondary Outcome Measures
Name Time Method numeric pain score 24 hours numeric pain score in 1, 2, 12, 24 hours after surgery
side effect of nefopam 24 hours side effect of nefopam: tachycardia, sweating, nausea, vomiting, sedation
Trial Locations
- Locations (1)
faculty of medicine Siriraj hospital
🇹ðŸ‡Bangkok, Thailand