Video-assisted thoracoscopic lobectomy (VATS) versus conventional Open Lobectomy for lung cancer

Not Applicable

Completed

• Conditions: ung cancer (stage cT1a-2b N0-1 M0); Cancer; Malignant neoplasm of bronchus and lung

• Registration Number: ISRCTN13472721
• Lead Sponsor: Royal Brompton & Harefield NHS Foundation Trust

Brief Summary

2019 Protocol article in https://pubmed.ncbi.nlm.nih.gov/31615795/ protocol 2022 Results article in https://doi.org/10.1056/EVIDoa2100016 results (added 27/01/2022) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/36524582/ (added 19/12/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-11-28
• Study Completion: 2020-09-01
• Last Update Posted: 5 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 503

Inclusion Criteria

Current participant inclusion criteria as of 08/01/2019:
1. Adults aged =16 years of age
2. Able to give written consent, undergoing either:
2.1. Lobectomy or bilobectomy for treatment of known or suspected primary lung cancer beyond lobar orifice* in TNM8 stage cT1-3 (by size criteria, equivalent to TNM7 stage cT1a-2b) or cT3 (by virtue of 2 nodules in the same lobe), N0-1 and M0 or
2.2. Undergoing frozen section biopsy with the intention to proceed with lobectomy or bilobectomy if primary lung cancer with a peripheral tumour beyond a lobar orifice* in TNM8 stage cT1-3 (by size criteria, equivalent to TNM7 stage cT1a-2b) or cT3 (by virtue of 2 nodules in the same lobe), N0-1 and M0 is confirmed
3. Disease suitable for both minimal access (VATS) and open surgery

Previous participant inclusion criteria:
1. Adults aged =16 years of age
2. Able to give written consent, undergoing either:
2.1. Lobectomy for treatment of known or suspected primary lung cancer beyond lobular orifice in stage cT1a-2b N0-1 M0 or
2.2. Undergoing frozen section biopsy with the intention to proceed with lobectomy if primary lung cancer with a peripheral tumour beyond a lobular orifice in stage cT1a-2b N0-1 M0 is confirmed
3. Disease suitable for both minimal access (VATS) and open surgery

Exclusion Criteria

1. Adults lacking capacity to consent
2. Previous malignancy that influences life expectancy
3. Patients in whom a pneumonectomy or non-anatomic resection (e.g. wedge dissection) is planned
4. Patients with a serious concomitant disorder that would compromise patient safety during surgery
5. Planned robotic surgery

Study & Design

• Study Type: Interventional
• Study Design: Not specified