Multi-center Imaging Genetics Studies in China

• Conditions: Schizophrenia; Major Depressive Disorders; Alzheimer Disease

• Registration Number: NCT02681822
• Lead Sponsor: Tianjin Medical University General Hospital

Brief Summary

To study the impact of genetic and environmental factors on high-level cognition associated neural circuits among healthy young Chinese Han subjects.

Detailed Description

The investigators plan to collect behavioral assessment and environmental factors data,peripheral blood sample, MRI brain images in more than 10,000 healthy young Chinese Han individuals in order to build the pathway from gene to high-level cognitive phenotypes.

Study Timeline

• Study Start: 2015-11
• Study First Submitted: 2016-02-07
• Study First Submitted QC: 2016-02-11
• Study First Posted: 2016-02-12
• Status Verified: 2019-04
• Last Update Submitted: 2019-04-08
• Last Update Posted: 2019-04-10
• Primary Completion: 2019-12
• Study Completion: 2020-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 10000

Inclusion Criteria

• aged 18-30
• Chinese Han
• right-handed
• without history of neuropsychiatric disease
• no substance addiction
• smoking

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Exclusion Criteria

• younger or elder than 18-30 year-old
• other ethnics
• with history of neuropsychiatric disease
• with history of neuropsychiatric disease among first,second and third degree relatives

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Brain structure and function measured by MRI scans	2 years	The participants will receive non-interventional multi-modal MRI scans, such as 3D-T1WI, DTI, DKI, ASL, REST-fmri, then the investigators can acquire the brain volume in region of interest, such as bilateral hippocampus.

Secondary Outcome Measures

Name	Time	Method
Childhood adversities as assessed by Childhood Trauma Questionnaire-Short Form (Chinese Version)	2 years	To investigate impact of the adversities in early life of participants on brain structure and function as well as the interaction effect of childhood adversities and genetic variations,such as 5-HTTLPR polymorphism.

Trial Locations

Locations (1)

Tianjin Medical University General Hospital; 🇨🇳 Tianjin, Tianjin, China