Multi-center Imaging Genetics Studies in China
试验速览
- 阶段
- 不适用
- 入组人数
- 10,000
- 试验地点
- 1
- 主要终点
- Brain structure and function measured by MRI scans
研究概览
简要总结
To study the impact of genetic and environmental factors on high-level cognition associated neural circuits among healthy young Chinese Han subjects.
详细描述
The investigators plan to collect behavioral assessment and environmental factors data,peripheral blood sample, MRI brain images in more than 10,000 healthy young Chinese Han individuals in order to build the pathway from gene to high-level cognitive phenotypes.
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged 18-30
- •Chinese Han
- •right-handed
- •without history of neuropsychiatric disease
- •no substance addiction
排除标准
- •younger or elder than 18-30 year-old
- •other ethnics
- •with history of neuropsychiatric disease
- •with history of neuropsychiatric disease among first,second and third degree relatives
结局指标
主要结局
Brain structure and function measured by MRI scans
时间窗: 2 years
The participants will receive non-interventional multi-modal MRI scans, such as 3D-T1WI, DTI, DKI, ASL, REST-fmri, then the investigators can acquire the brain volume in region of interest, such as bilateral hippocampus.
次要结局
- Childhood adversities as assessed by Childhood Trauma Questionnaire-Short Form (Chinese Version)(2 years)
研究者
Chunshui Yu
Head of Department of Radiology and Tianjin Key Laboratory of Functional Imaging
Tianjin Medical University General Hospital