NL-OMON33914
Completed
Not Applicable
Genetic and environmental influences on the brain, the immunesystem and gene expression in bipolar twin pairs - a cross-sectional and longitudinal study - Brain, immune system, gene expression in BP twins
niversitair Medisch Centrum Utrecht0 sites420 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- manic depressive disorder
- Sponsor
- niversitair Medisch Centrum Utrecht
- Enrollment
- 420
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Study A\+B (longitudinal):
- •participation at baseline;Study A\+B\+C\+D (cross\-sectional)
- •New bipolar twin pairs
- •1\) Part of a monozygotic or dizygotic twin pair
- •2\) At least one twin has a diagnoses (life time) of Bipolar Disorder I or Bipolar Disorder II (DSM\-IV criteria)
- •3\) No history of drug or alcohol dependency (DSM\-IV criteria) for the last half year
- •4\) No history of Cognitive Disorder (DSM\-IV criteria)
- •5\) No history of serious neurological illness
- •6\) No severe medical illness
- •7\) Age between 18 and 60 years;New healthy control twin pairs
Exclusion Criteria
- •Did not give written informed consent
- •2\) Ferrous objects in or around the body (e.g. braces, glasses, pacemaker, metal fragments)
- •3\) Drug or alcohol abuse over a period of six months prior to the experiment
- •4\) History of closed\-head injury
- •5\) History of neurological illness or endocrinological dysfunction
- •6\) Claustrophobia
Outcomes
Primary Outcomes
Not specified
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