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临床试验/NCT02283931
NCT02283931暂停不适用

Assessement of Hemodynamic Changes Associated With Uterine Displacement Using Noninvasive Cardiac Output Monitoring and Transthoracic Echocardiography:

Brigham and Women's Hospital2 个研究点 分布在 1 个国家目标入组 25 人开始时间: 2015年1月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
暂停
入组人数
25
试验地点
2
主要终点
Cardiac Output

研究概览

简要总结

There is currently little information regarding the hemodynamic differences in uterine displacement techniques. Previous studies examining the hemodynamic effects of uterine displacement maneuvers have focused on incidence of hypotension and use of ephedrine.

Noninvasive cardiac output monitoring (NICOM) and transthoracic echocardiography (TTE) are becoming popular techniques in anesthesiology because they can provide noninvasive, valid, and precise hemodynamic data.There has been no study specifically examining the hemodynamic differences between the uterine displacement techniques using NICOM or TTE. While all three uterine displacement techniques are recommended, whether one technique may maximize maternal cardiac output is currently unknown.

详细描述

Aortocaval compression is a well-recognized physiologic concern in pregnancy. The gravid uterus can compress the inferior vena cava, impeding venous return and thereby reducing stroke volume and cardiac output.

The 2014 Society for Obstetric Anesthesia and Perinatology consensus statement on the management of cardiac arrest in pregnancy, and the 2010 American Heart Association guideline on maternal cardiac arrest recommend relieving aortocaval compression during chest compressions by performing uterine displacement There is currently little information regarding the hemodynamic differences amongst the recommended uterine displacement techniques. Previous studies examining the hemodynamic effects of uterine displacement maneuvers have focused on incidence of hypotension and use of ephedrine.

Noninvasive cardiac output monitoring (NICOM) and transthoracic echocardiography (TTE) are becoming popular techniques in anesthesiology because they can provide noninvasive, valid, and precise hemodynamic data.There has been no study specifically examining the hemodynamic differences between the uterine displacement techniques using NICOM or TTE. While all three uterine displacement techniques are recommended, whether one technique may maximize maternal cardiac output is currently unknown.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Diagnostic
盲法
None

入排标准

年龄范围
18 Years 至 50 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • Healthy ASA physical status I-II
  • Term parturient

排除标准

  • Woman in labor
  • Presence of maternal medical conditions affecting the cardiovascular system (including preeclampsia, gestational hypertension)
  • Fetal anomaly or intrauterine growth restriction (< 25th percentile)
  • Maternal renal or endocrine disease

研究组 & 干预措施

One handed uterine displacement

Active Comparator

Uterine displacement using one hand

干预措施: TTE / NICOM (Device)

two handed uterine displacement

Active Comparator

Uterine displacement using two hands

干预措施: TTE / NICOM (Device)

30 degrees uterine displacement

Active Comparator

Uterine displacement using a 30 degrees wedge

干预措施: TTE / NICOM (Device)

结局指标

主要结局

Cardiac Output

时间窗: 10 minutes

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Lawrence Ching Tsen

Associate Professor, Harvard Medical School

Brigham and Women's Hospital

研究点 (2)

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