Evaluation of the Efficacy of Intranasal Salmon Calcitonin on Bone Healing Following Surgical Removal of Impacted Mandibular Third Molars — A Randomized Controlled Clinical Trial
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- A total of 100 patients will be randomly divided into two groups: Group I will receive intranasal salmon calcitonin along with standard postoperative care, while Group II will receive only standard care.
研究概览
简要总结
This randomized controlled study will evaluate the efficacy of salmon calcitonin nasal spray on bone healing and postoperative pain following surgical removal of impacted third molar. A total of 100 patients will be randomly divided into two groups : Group 1 will receive intranasal salmon calcitonin along with standard postoperative care, while group 2 will receive standard care. Post op pain will be assessed using Visual Analogue Scale VAS on day 1,7,14,21 and 30, and bone healing will be evaluated by radiographic assessment of bone density at extraction site immediately after surgery, at 4 weeks and 12 weeks.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with impacted mandibular third molar.
- •Pederson difficulty index score of 6 and above.
- •Patients in the age group between 18 to 40 years ASA-1 category.
排除标准
- •Patients with seafood alleregy Patients with Peri apical pathology ASA-2,3,4,5 and 6 CATEGORIES Patient with any previous history of cardiomyopathy Patient with any known history of Thyroid dysfunction.
- •Patient undergoing therapies with bisphosphonates and immunosuppressants.
- •Patient with any known history of osteoporosis or pathologic fractures.
- •Asthmatic patients.
结局指标
主要结局
A total of 100 patients will be randomly divided into two groups: Group I will receive intranasal salmon calcitonin along with standard postoperative care, while Group II will receive only standard care.
时间窗: Postoperative pain will be assessed using the Visual Analog Scale on days 1, 7, 14, 21, and 30.
次要结局
- bone healing will be evaluated by radiographic assessment of bone density at the extraction site immediately after surgery.(Assessed at 4 weeks, and at 12 weeks.)
研究者
Harni N
Madha Dental College