Vasopressin Deficiency in Hemorrhagic Shock

Completed

• Conditions: Body Response to Trauma
• Interventions: Other: Phlebotomy

• Registration Number: NCT01107314
• Lead Sponsor: The University of Texas Health Science Center at San Antonio

Brief Summary

In this study we hope to delineate the typical vasoactive mediator response of trauma patients to shock. We plan to assess serum levels of vasopressin and also catecholamines, angiotensin, and cortisol during resuscitation of trauma patients to delineate high risk populations for vasopressin deficiency.

Detailed Description

This is a prospective observational study. The only research-driven procedure will be the removal of blood samples at designated time points(total blood removed 48 cc per patient). Hemodynamic, fluid infusion and agitation/pain data (RAMSEY Score) will prospectively be collected for research purposes. We will collect data from a convenience sample of patients (when research staff is available) over a one year period.

Study Timeline

• Study Start: 2010-02
• Study First Submitted: 2010-04-19
• Study First Submitted QC: 2010-04-19
• Study First Posted: 2010-04-20
• Primary Completion: 2011-04-30
• Study Completion: 2011-04-30
• Status Verified: 2012-03
• Last Update Submitted: 2018-01-12
• Last Update Posted: 2018-01-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 81

Inclusion Criteria

• Patient is a male or female patient presumed to be at least 18 years of age;
• Patient has a reported or actual systolic blood pressure < 90 mmHg within 1 hour of arrival to the Emergency Room;
• Patient has clinical evidence of acute traumatic injury;

Exclusion Criteria

• Patient is asystolic or requires CPR prior to arrival;
• Patient was transferred from an outside facility
• Patient known to be pregnant
• Patient known to be prisoner

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
trauma patient	Phlebotomy	SBP less than 90mmHg

Trial Locations

Locations (1)

UTHSCSA; 🇺🇸 San Antonio, Texas, United States