Pathogenesis of long bone fractures in Vitamin D deficient childre

Phase 4

• Conditions: Vitamin D deficiency; Fractures; Musculoskeletal - Other muscular and skeletal disorders; Injuries and Accidents - Fractures; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12614000967684
• Lead Sponsor: niversity of Melbourne

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-09-09
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Age between 8 & 18 at time of recruitment
Voluntary informed consent provided by parent/guardian and children and adolescents aged over 10 years
Presentation within ten days of injury
Conservatively managed fractures including those undergoing a closed manipulation within 24 hours of injury

Exclusion Criteria

Age younger than 8 or older than 18 years of age at the commencement of the study
Voluntary informed consent not provided by a parent/guardian and/or children and adolescents aged over 10 years
Fractures managed with an open operation
Fractures manipulated after 24 hours from time of injury
Fracture through a previous fracture site
Fractures consisting of either plastic deformity only

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fracture callous density as assessed by peripheral quantitative computed tomography.[Six weeks]

Secondary Outcome Measures

Name	Time	Method
Bone density as assessed by peripheral quantitative computed tomography[Six weeks];Muscle strength evaluated by isometric testing and muscle cross-sectional area as calculated by peripheral quantitative computed tomography.[Six weeks]