Brain development, brain functioning, growth and metabolic aspects in the clinical management of transsexual adolescents.
- Conditions
- gender identity disordertranssexuality10037176
- Registration Number
- NL-OMON30547
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 244
Inclusion criteria pubertal patients: girls and boys with transsexualism who are eligible for sex reassignment according to psychologist and psychiatrist (if they are older than 12 years, psychologically stable and live in a stable social environment) . Girls have to be in stage B2 and boys in G2-G3 with measurable estradiol and testosterone levels respectively.
Inclusion criteria pre-pubertal patients: girls and boys with high probability of transsexualism according to psychologist or psychiatrist and the age of 9-12 years. Girls have to be in an earlier stage than B2 and boys in an earlier stage than G2-G3.
Inclusion criteria healthy subjects: girls and boys who are similar aged friends of transsexual patients
Exclusion criteria patients: intersex conditions
Exclusion criteria healthy subjects: puberty delaying treatment or hormonal therapy, oral anticonception users are not excluded
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>* Cognition: performance and reaction time on three cognition tasks (verbal<br /><br>fluency task, mental rotation task and emotional faces task)<br /><br>* Functional MRI: data during the verbal fluency task, mental rotation task and<br /><br>emotional faces task.<br /><br>* Structural MRI: data on total brain volume, gray and white matter (amount and<br /><br>percentage), CSF, volume frontal and temporal lobe, gyrification, brain<br /><br>asymmetry. ROI analysis of basal ganglia, amygdala, hippocampus, corpus<br /><br>callosum, hypothalamus</p><br>
- Secondary Outcome Measures
Name Time Method <p>* score from -10 to 10 on handedness questionairre<br /><br>* performance score on adapted WISC-III questionairre (4 items: 2 performance,<br /><br>2 verbal)<br /><br>* information about psychological functioning (parent questionairre)<br /><br>* anthropometric data, information about pubertal stage according to Tanner<br /><br>* information about homosexuality/ transsexuality in familymembers<br /><br>* digital photographs and physical appearance list (14 items)</p><br>