Brain Structure and Development in Children and Adolescents with Prader-Willi Syndrome: A Combined Structural and Functional MRI Study
Recruiting
- Conditions
- Prader-Willi Syndrome10083624
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 160
Inclusion Criteria
Children and adolescents with genetically confirmed PWS and known genetic defect between 6-25 years old and healthy age- and sex-matched controls
Written Informed consent of the caregivers and children and adolescents older than 12 years and assent of patients/children younger than 12 years
Written informed consent of healthy adult controls
Successful completion of the mock MRI scanner protocol for healthy controls under 12 years old
Exclusion Criteria
Other chromosomal abnormalities
Claustrophobia
Contra-indications for MRI scanner
The use of medication for treating anxiety, mood disorders or psychiatric disturbances including the regular use of homeopathic St John*s wort preparations for longer than two weeks
Expected or proven non-compliance
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>We will measure multiple parameters such as total brain volume, grey<br /><br>matter/white matter volume, volumes of various brain structures (such as<br /><br>pituitary gland, caudate nucleus, hippocampus, hypothalamus), white matter<br /><br>connections (corpus callosum, anterior and posterior commisures), connectivity<br /><br>within the different lobes. We will further investigate the known functional<br /><br>networks within the brain by means of resting state fMRI. Longitudinal changes<br /><br>in structure and function will be assessed as well. </p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>